Phenotypes associated with this allele

• Allele Symbol: Dusp22^tm1Tht
• Allele Name: targeted mutation 1, Tse-Hua Tan
• Allele ID: MGI:6368881
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dusp22^tm1Tht/Dusp22^tm1Tht	B6.129S7-Dusp22^tm1Tht	MGI:6379996

Genotype
MGI:6379996

hm1

• Allelic Composition: Dusp22^tm1Tht/Dusp22^tm1Tht
• Genetic Background: B6.129S7-Dusp22^tm1Tht

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:213253 )

• aged mice exhibit splenomegaly

increased spleen white pulp amount ( J:213253 )

• aged mice show expansion of white pulps in spleens

abnormal B cell activation ( J:213253 )

• B-cells show decreased cell activation and proliferation on anti-IgM stimulation

• however, B-cell development is normal

decreased B cell proliferation ( J:213253 )

• B-cells show decreased proliferation on anti-IgM stimulation

decreased immunoglobulin level ( J:213253 )

• T-cell dependent antibody production in the serum is moderately reduced after primary and secondary immunization

decreased IgG3 level ( J:213253 )

• mice immunized with a T-cell independent antigen, Ficoll, show decreased IgG3 levels

decreased IgM level ( J:213253 )

• mice immunized with a T-cell independent antigen, Ficoll, show decreased IgM levels

abnormal T cell activation ( J:213253 )

• activation of T-cells by anti-CD3 stimulation results in a higher level of T-cell activation markers, an increase in T-cell cell divisions, and enhanced calcium flux responses

• CD4+ and CD8+ T cells exhibit increased T-cell activation on anti-CD3 stimulation

• however, T-cell development is normal, with normal development of thymus-derived T regulatory cells, and function of spleen-derived Treg is unaffected

increased T cell proliferation ( J:213253 )

• CD4+ and CD8+ T cells exhibit increased T-cell proliferation and activation on anti-CD3 stimulation

• T-cells from KLH-immunized mice show enhanced proliferation on KLH restimulation

abnormal cytokine level ( J:213253 )

• serum levels of proinflammatory cytokines are elevated in 24, 48, and 72 week old mice

increased circulating interferon-gamma level ( J:213253 )

• serum levels of IFN-gamma are elevated in 24, 48, and 72 week old mice

• KLH-immunized mice show higher serum IFN-gamma levels

increased circulating interleukin-17 level ( J:213253 )

• serum levels of IL-17 are elevated in 24, 48, and 72 week old mice

• KLH-immunized mice show higher IL-17 levels

increased circulating interleukin-6 level ( J:213253 )

• serum levels of IL-6 are elevated in 24, 48, and 72 week old mice

increased circulating tumor necrosis factor level ( J:213253 )

• serum levels of TNF-alpha are elevated in 24, 48, and 72 week old mice

increased interferon-gamma secretion ( J:213253 )

• T-cells produce more IFN-gamma than wild-type cells upon activation with anti-CD3 stimulation

• T-cells from KLH-immunized mice produce more IFN-gamma

increased interleukin-17 secretion ( J:213253 )

• T-cells from KLH-immunized mice produce more IL-17

increased interleukin-2 secretion ( J:213253 )

• T-cells produce more IL-2 than wild-type cells upon activation with anti-CD3 stimulation

• CD4+ T cells show increased IL-2 production on TCR signaling

increased interleukin-4 secretion ( J:213253 )

• T-cells from KLH-immunized mice produce more IL-4

increased susceptibility to autoimmune disorder ( J:213253 )

• aged mice develop systemic inflammation and autoimmune disease

increased susceptibility to experimental autoimmune encephalomyelitis ( J:213253 )

• mice develop faster and more severe experimental autoimmune encephalomyelitis (EAE) when immunized with myelin oligodendrocyte glycoprotein (MOG) peptides

• levels of proinflammatory cytokines IFN-gamma and IL-17 in the sera are increased in EAE-induced mice

• infiltrating CD4+ T cells in the brain are increased in EAE-induced mice

• infiltrating IFN-gamma+ Th1 cells and IL-17+ Th17 cells in the brain and spinal cord are increased in EAE-induced mice

• mice in which mutant CD4+ T cells were adoptively transferred into irradiated recipient mice develop more severe EAE when immunized with MOG peptides and receipient mice that are passively transferred with the ecephalitogenic CD4+ T cells from EAE-diseased mutant mice are mores susceptible to EAE induction

• splenic T cells restimulated with MOG peptides show enhanced proliferation, increased IL-2, IFN-gamma, and IL-17 production

increased inflammatory response ( J:213253 )

• aged mice show massive infiltration of lymphocytes in liver periportal areas, lungs, and rental tubules indicating systemic inflammation

liver inflammation ( J:213253 )

• aged mice show massive infiltration of lymphocytes in liver periportal areas

kidney inflammation ( J:213253 )

• aged mice show massive infiltration of lymphocytes in renal tubules and of mononuclear cells in kidneys

lung inflammation ( J:213253 )

• aged mice show massive infiltration of lymphocytes in lungs

liver/biliary system

liver inflammation ( J:213253 )

• aged mice show massive infiltration of lymphocytes in liver periportal areas

respiratory system

lung inflammation ( J:213253 )

• aged mice show massive infiltration of lymphocytes in lungs

hematopoietic system

enlarged spleen ( J:213253 )

• aged mice exhibit splenomegaly

increased spleen white pulp amount ( J:213253 )

• aged mice show expansion of white pulps in spleens

abnormal B cell activation ( J:213253 )

• B-cells show decreased cell activation and proliferation on anti-IgM stimulation

• however, B-cell development is normal

decreased B cell proliferation ( J:213253 )

• B-cells show decreased proliferation on anti-IgM stimulation

decreased immunoglobulin level ( J:213253 )

• T-cell dependent antibody production in the serum is moderately reduced after primary and secondary immunization

decreased IgG3 level ( J:213253 )

• mice immunized with a T-cell independent antigen, Ficoll, show decreased IgG3 levels

decreased IgM level ( J:213253 )

• mice immunized with a T-cell independent antigen, Ficoll, show decreased IgM levels

abnormal T cell activation ( J:213253 )

• activation of T-cells by anti-CD3 stimulation results in a higher level of T-cell activation markers, an increase in T-cell cell divisions, and enhanced calcium flux responses

• CD4+ and CD8+ T cells exhibit increased T-cell activation on anti-CD3 stimulation

• however, T-cell development is normal, with normal development of thymus-derived T regulatory cells, and function of spleen-derived Treg is unaffected

increased T cell proliferation ( J:213253 )

• CD4+ and CD8+ T cells exhibit increased T-cell proliferation and activation on anti-CD3 stimulation

• T-cells from KLH-immunized mice show enhanced proliferation on KLH restimulation

homeostasis/metabolism

abnormal cytokine level ( J:213253 )

• serum levels of proinflammatory cytokines are elevated in 24, 48, and 72 week old mice

increased circulating interferon-gamma level ( J:213253 )

• serum levels of IFN-gamma are elevated in 24, 48, and 72 week old mice

• KLH-immunized mice show higher serum IFN-gamma levels

increased circulating interleukin-17 level ( J:213253 )

• serum levels of IL-17 are elevated in 24, 48, and 72 week old mice

• KLH-immunized mice show higher IL-17 levels

increased circulating interleukin-6 level ( J:213253 )

• serum levels of IL-6 are elevated in 24, 48, and 72 week old mice

increased circulating tumor necrosis factor level ( J:213253 )

• serum levels of TNF-alpha are elevated in 24, 48, and 72 week old mice

cellular

decreased B cell proliferation ( J:213253 )

• B-cells show decreased proliferation on anti-IgM stimulation

increased T cell proliferation ( J:213253 )

• CD4+ and CD8+ T cells exhibit increased T-cell proliferation and activation on anti-CD3 stimulation

• T-cells from KLH-immunized mice show enhanced proliferation on KLH restimulation

renal/urinary system

kidney inflammation ( J:213253 )

• aged mice show massive infiltration of lymphocytes in renal tubules and of mononuclear cells in kidneys

abnormal renal glomerulus morphology ( J:213253 )

• kidneys from aged mice show glomerulomegaly with hypersegmentation

• kidneys of aged mice show more pronounced glomerular damage, massive mononuclear cell infiltration and tubulointerstitial injury (mesangial hypertrophy and tubulointerstitial injury

abnormal glomerular mesangium morphology ( J:213253 )

• aged mice show mesangial hypertrophy

increased renal glomerulus lobularity ( J:213253 )

• aged mice show hypersegmented glomeruli

growth/size/body

enlarged spleen ( J:213253 )

• aged mice exhibit splenomegaly