Phenotypes associated with this allele

• Allele Symbol: Crisp2^{tm1c(KOMP)Mbp}
• Allele Name: targeted mutation 1c, Mouse Biology Program, UC Davis
• Allele ID: MGI:6369005
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Crisp2^tm1c(KOMP)Mbp/Crisp2^tm1c(KOMP)Mbp Tg(Stra8-icre)1Reb/0	involves: C57BL/6N * FVB/NJ	MGI:6369095

Genotype
MGI:6369095

cn1

• Allelic Composition: Crisp2^{tm1c(KOMP)Mbp}/Crisp2^{tm1c(KOMP)Mbp}; Tg(Stra8-icre)1Reb/0
• Genetic Background: involves: C57BL/6N * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:273472 )

♀N • female fertility is similar to controls

decreased sperm progressive motility ( J:273472 )

♂ • significant reduction in the percentage of sperm displaying rapid forms of progressive motility

asthenozoospermia ( J:273472 )

♂ • show a 28.7% reduction in the number of sperm showing any form of motility

reduced male fertility ( J:273472 )

♂ • males are sub-fertile

♂ • however, testes weight and sperm production and histology are similar to controls

impaired acrosome reaction ( J:273472 )

♂ • decrease in the percentage of sperm that undergo progesterone-evoked acrosome reaction

cellular

decreased sperm progressive motility ( J:273472 )

♂ • significant reduction in the percentage of sperm displaying rapid forms of progressive motility

asthenozoospermia ( J:273472 )

♂ • show a 28.7% reduction in the number of sperm showing any form of motility