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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plet1em1Yhh
endonuclease-mediated mutation 1, Yina H Huang
MGI:6369063
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plet1em1Yhh/Plet1em1Yhh Not Specified MGI:6369064


Genotype
MGI:6369064
hm1
Allelic
Composition		 Plet1em1Yhh/Plet1em1Yhh
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plet1em1Yhh mutation (0 available); any Plet1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor susceptibility ( J:251136 )
• substantially reduced tumor numbers in the AOM/DSS colon cancer model

digestive/alimentary system
abnormal intestine physiology ( J:251136 )
• significantly increased gut permiability

homeostasis/metabolism
impaired wound healing ( J:251136 )
• impaired tissue repair of DSS-induced damage in colon epithelium




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory