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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Osbpem1(IMPC)Tcp
endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI:6369352
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Osbpem1(IMPC)Tcp/Osbpem1(IMPC)Tcp C57BL/6NCrl-Osbpem1(IMPC)Tcp/Cmmr MGI:7414995
ht2
 		Osbpem1(IMPC)Tcp/Osbp+ C57BL/6NCrl-Osbpem1(IMPC)Tcp/Cmmr MGI:7414994


Genotype
MGI:7414995
hm1
Allelic
Composition		 Osbpem1(IMPC)Tcp/Osbpem1(IMPC)Tcp
Genetic
Background		 C57BL/6NCrl-Osbpem1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osbpem1(IMPC)Tcp mutation (2 available); any Osbp mutation (29 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Osbpem1(IMPC)Tcp/Osbpem1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida but form irregular outgrowths with no inner cell mass colony or trophoblast giant cells after 3 days in culture.

embryo
absent inner cell mass ( J:279207 )
• in vitro outgrowth assays show no apparent inner cell mass (ICM) colony after 3 days in culture
absent trophoblast giant cells ( J:279207 )
• in vitro, no trophoblast giant cells (TGCs) are apparent after 3 days in culture

mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )
• early blastocysts are present at E3.5 (12% versus expected 25%, n=24); no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system
abnormal embryo implantation ( J:279207 )
• in vitro, blastocysts hatch from the zona pellucida but form very irregular outgrowths after 3 days in culture




Genotype
MGI:7414994
ht2
Allelic
Composition		 Osbpem1(IMPC)Tcp/Osbp+
Genetic
Background		 C57BL/6NCrl-Osbpem1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osbpem1(IMPC)Tcp mutation (2 available); any Osbp mutation (29 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system

integument

skeleton




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory