Phenotypes associated with this allele

• Allele Symbol: Rcn2^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6369411
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rcn2^tm1b(KOMP)Wtsi/Rcn2^tm1b(KOMP)Wtsi	involves: C3H * C57BL/6 * C57BL/6N	MGI:6369414

Genotype
MGI:6369414

hm1

• Allelic Composition: Rcn2^{tm1b(KOMP)Wtsi}/Rcn2^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart rate ( J:280163 )

♂ • mice infused with angiotensin II exhibit a faster heart rate than wild-type mice

decreased systemic arterial blood pressure ( J:280163 )

♂ • average systolic and diastolic blood pressure is lower in males

decreased susceptibility to hypertension ( J:280163 )

♂ • mice infused with angiotensin II to induce hypertension show a smaller rise in systolic blood pressure than wild-type mice

abnormal blood vessel physiology ( J:280163 )

♂ • isolated carotid arteries show an increased sensitivity to acetylcholine-induced nitric oxide-mediated relaxant response, showing a larger artery dilation

renal/urinary system

renal/urinary system phenotype ( J:280163 )

♂N • kidney function is normal