Phenotypes associated with this allele

• Allele Symbol: Mir425^em1Nju
• Allele Name: endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• Allele ID: MGI:6369665
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mir425^em1Nju/Mir425^+	involves: C57BL/6	MGI:6369793

Genotype
MGI:6369793

ht1

• Allelic Composition: Mir425^em1Nju/Mir425⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to dopaminergic neuron neurotoxicity ( J:280159 )

♂ • mice treated with the neurotoxin MPTP to induce Parkinson disease-like pathology show fewer TH neurons and fewer DAT-positive neurons indicating increased dopaminergic degeneration

♂ • marker analysis indicates more highly activated necroptosis in dopaminergic neurons following MPTP treatment

loss of dopaminergic neurons ( J:280159 )

♂ • dopaminergic neuron loss in the substantia nigra par compacta is seen at 15 months of age, but not at 3 or 6 months

behavior/neurological

impaired behavioral response to xenobiotic ( J:280159 )

♂ • mice exhibit more severe motor dysfunction after MPTP treatment, showing less mobile time with decreased motor activity in the open field test and shorter coordination time in the rotarod test

cellular

increased susceptibility to dopaminergic neuron neurotoxicity ( J:280159 )

♂ • mice treated with the neurotoxin MPTP to induce Parkinson disease-like pathology show fewer TH neurons and fewer DAT-positive neurons indicating increased dopaminergic degeneration

♂ • marker analysis indicates more highly activated necroptosis in dopaminergic neurons following MPTP treatment

homeostasis/metabolism

increased susceptibility to dopaminergic neuron neurotoxicity ( J:280159 )

♂ • mice treated with the neurotoxin MPTP to induce Parkinson disease-like pathology show fewer TH neurons and fewer DAT-positive neurons indicating increased dopaminergic degeneration

♂ • marker analysis indicates more highly activated necroptosis in dopaminergic neurons following MPTP treatment

immune system

increased tumor necrosis factor secretion ( J:280159 )

♂ • MPTP-treated mice show increased inflammatory cytokine TNF-alpha release in the brain