Phenotypes associated with this allele

• Allele Symbol: Clec4b1^em#Tsak
• Allele Name: endonuclease-mediated mutation, Tetsushi Sakuma
• Allele ID: MGI:6369851
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clec4b1^em#Tsak/Clec4b1^em#Tsak	involves: C57BL/6N	MGI:6369854

Genotype
MGI:6369854

hm1

• Allelic Composition: Clec4b1^em#Tsak/Clec4b1^em#Tsak
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine level ( J:258645 )

• production of the cytokines/chemokines monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2) and IL-6 upon stimulation with acylated phosphatidyl-inositol mannosides is lower in peritoneal exudate cells

• mice infected with M. bovis show lower production of MCP-1 in the peritoneal cavity

• mice infected with M. tuberculosis produce less MCP-1 in infection sites

abnormal adaptive immunity ( J:258645 )

• mice exhibit impaired immune response during mycobacterial infection

• mice infected with M. bovis BCG do not show an accumulation of small peritoneal macrophages upon infection

• accumulation of monocyte-derived inflammatory cells in lungs, mediastinal lymph nodes, and spleen after M. bovis infection is impaired

abnormal cytokine secretion ( J:258645 )

• mice injected with acylated phosphatidyl-inositol mannosides intraperitoneally show reduced MCP-1, MIP-2, and IL-6 secretion in the peritoneal cavity

decreased interferon-gamma secretion ( J:258645 )

• less IFN-gamma is secreted from peritoneal T cells and splenic T cells from M. bovis infected mutant mice than wild-type after re-stimulation with purified protein derivative

• levels of IFN-gamma in the peritoneal cavity of M. bovis infected mice are lower than in controls

• mice infected with M. bovis through the airways show reduced IFN-gamma production from mediastinal lymph node cells

decreased interleukin-12 secretion ( J:258645 )

• levels of IL-12 in the peritoneal cavity of M. bovis infected mice are lower than in wild-type mice

increased susceptibility to bacterial infection ( J:258645 )

• upon mycobacterial M. bovis infection, mice show reduced numbers of monocyte-derived inflammatory cells at the infection site, impaired IFN-gamma production by T cells, and an increased bacterial load

• mice infected with M. bovis through airways, show reduced IFN-gamma production from mediastinal lymph node cells and higher bacterial loads in the lungs

• upon M. tuberculosis infection, mice produce less MCP-1 in infection sites and have higher average bacterial abundance than controls

homeostasis/metabolism

abnormal cytokine level ( J:258645 )

• production of the cytokines/chemokines monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2) and IL-6 upon stimulation with acylated phosphatidyl-inositol mannosides is lower in peritoneal exudate cells

• mice infected with M. bovis show lower production of MCP-1 in the peritoneal cavity

• mice infected with M. tuberculosis produce less MCP-1 in infection sites