Phenotypes associated with this allele

• Allele Symbol: Cad^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6376189
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cad^tm1c(KOMP)Wtsi/Cad^tm1c(KOMP)Wtsi Tg(Adipoq-rtTA)2Zvw/0 Tg(tetO-cre)1Jaw/0	involves: 129 * C57BL/6 * C57BL/6N	MGI:6376235
cn2	Cad^tm1c(KOMP)Wtsi/Cad^tm1c(KOMP)Wtsi Tg(Adipoq-rtTA)2Zvw/0 Tg(tetO-cre)1Jaw/0 Tg(tetO-Xbp1_is)#Pesch/0	involves: 129 * C57BL/6 * C57BL/6N * FVB/N	MGI:6376231

Genotype
MGI:6376235

cn1

• Allelic Composition: Cad^{tm1c(KOMP)Wtsi}/Cad^{tm1c(KOMP)Wtsi}; Tg(Adipoq-rtTA)2Zvw/0; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6N
• Cell Lines: EPD0282_2_F10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased white fat cell size ( J:260830 )

• mice show a moderate size reduction of adipocytes in subcutaneous white adipose tissue (sWAT) when fed a Dox-containing diet

• however, no differences in epididymal white adipose tissue (eWAT) or interscapular brown adipose tissue (BAT) adipocyte size is seen

growth/size/body

growth/size/body region phenotype ( J:260830 )

N • mice do not show differences in bodyweight gain from wild-type mice when treated with doxycycline (Dox)

Genotype
MGI:6376231

cn2

• Allelic Composition: Cad^{tm1c(KOMP)Wtsi}/Cad^{tm1c(KOMP)Wtsi}; Tg(Adipoq-rtTA)2Zvw/0; Tg(tetO-cre)1Jaw/0; Tg(tetO-Xbp1_is)#Pesch/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6N * FVB/N
• Cell Lines: EPD0282_2_F10

growth/size/body

weight loss ( J:260830 )

• mice continue to increase their body weight when switched to a doxycycline (Dox)-containing diet, although not at the same extent as wild-type mice thus showing a partial reversal of weight loss

adipose tissue

adipose tissue phenotype ( J:260830 )

N • size of adipocytes is epididymal white adipose tissue (eWAT), subcutaneous white adipose tissue (sWAT), and in interscapular brown adipose tissue (BAT)is normal in Dox-treated mice

N • adipose tissue uridine content is not increased and thus rescued in Dox-treated mice compared to Tg(tetO-Xbp1_is)#Pesch/0 Tg(Adipoq-rtTA)2Zvw/0 mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:260830 )

N • adipose tissue uridine content is not increased and thus rescued in Dox-treated mice compared to Tg(tetO-Xbp1_is)#Pesch/0 Tg(Adipoq-rtTA)2Zvw/0 mice