Phenotypes associated with this allele

• Allele Symbol: Echdc1^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6376198
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Echdc1^em1(IMPC)J/Echdc1^em1(IMPC)J	C57BL/6NJ-Echdc1^em1(IMPC)J/Mmjax	MGI:6696727

Genotype
MGI:6696727

hm1

• Allelic Composition: Echdc1^em1(IMPC)J/Echdc1^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Echdc1^em1(IMPC)J/Mmjax

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:346664 )

♂ • 8-week-old male mice fed a standard chow diet show a significant increase in plasma total cholesterol levels relative to wild-type controls

♂ • however, hepatic concentration of cholesterol and liver mRNA expression of cholesterol genes (Srebp2, Hmgcs1, Hmgcr, and Fdft1) are relatively normal

increased circulating LDL cholesterol level ( J:346664 )

♂ • male mice fed a standard chow diet show an increased plasma cholesterol concentration within LDL fractions

♂ • however, the abundance of LDL particles is normal as measured by ApoB protein abundance

increased circulating VLDL cholesterol level ( J:346664 )

♂ • male mice fed a standard chow diet show an increased plasma cholesterol concentration within VLDL fractions

increased circulating triglyceride level ( J:346664 )

♂ • male mice fed a standard chow diet show a significant increase in plasma triglyceride levels relative to wild-type controls

♂ • however, hepatic concentration of triglycerides is relatively normal

increased circulating VLDL triglyceride level ( J:346664 )

♂ • male mice fed a standard chow diet show an increased plasma triglyceride concentration within VLDL fractions

♂ • however, the abundance of VLDL particles is normal as measured by ApoB protein abundance