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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ess2tm1.1Nbioc
targeted mutation 1.1, Nihon University School of Medicine , Division of Biochemistry, Department of Biomedical Sciences
MGI:6376226
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ess2tm1.1Nbioc/Ess2tm1.1Nbioc
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6N * DBA/2 MGI:7548678


Genotype
MGI:7548678
cn1
Allelic
Composition		 Ess2tm1.1Nbioc/Ess2tm1.1Nbioc
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ess2tm1.1Nbioc mutation (0 available); any Ess2 mutation (29 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:339504 )
N
• mice exhibit normal double negative to double positive selection in the thymus
decreased CD8-positive, naive alpha-beta T cell number ( J:339504 )
• reduced peripheral naive T cells
abnormal CD4-positive, alpha-beta T cell physiology ( J:339504 )
• CD4+ T cells do not maintain survival in response to IL-7 unlike control cells

hematopoietic system
decreased CD8-positive, naive alpha-beta T cell number ( J:339504 )
• reduced peripheral naive T cells
abnormal CD4-positive, alpha-beta T cell physiology ( J:339504 )
• CD4+ T cells do not maintain survival in response to IL-7 unlike control cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory