Phenotypes associated with this allele

• Allele Symbol: Dok3^tm1Kplm
• Allele Name: targeted mutation 1, Kong-Peng Lam
• Allele ID: MGI:6376621
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dok3^tm1Kplm/Dok3^tm1Kplm	involves: 129P2/OlaHsd	MGI:6376622

Genotype
MGI:6376622

hm1

• Allelic Composition: Dok3^tm1Kplm/Dok3^tm1Kplm
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell physiology ( J:280795 )

• B-cells exhibit enhanced T-cell independent immune responses

• however, mice show no perturbation in B cell generation or maturation and show normal B cell responses to T-cell dependent antigens

increased B cell proliferation ( J:280795 )

• B cells are hyperresponsive to BCR stimulation (cross-linking of BCR by anti-IgM (Fab)2 fragments) in vitro, showing increased proliferation compared to wild-type B cells

abnormal B cell calcium ion homeostasis ( J:280795 )

• at both low and high dose BCR stimulation, B cells show a much higher level of calcium signaling

increased IgG3 level ( J:280795 )

• mice immunized with the T-cell independent type I antigen NP-Ficoll secrete greater amounts of antigen-specific IgM and IgG3 antibodies

increased IgM level ( J:280795 )

• increase in IgM antibodies in sera

• however, levels of other Ig classes are similar to wild-type mice

• mice immunized with the T-cell independent type I antigen NP-LPS secrete greater amounts of antigen-specific IgM antibodies

• mice immunized with the T-cell independent type I antigen NP-Ficoll secrete greater amounts of antigen-specific IgM and IgG3 antibodies

enhanced humoral immune response ( J:280795 )

• mice mount enhanced humoral immune responses to T-cell independent type I and II antigens, secreting greater amounts of antigen-specific IgM and IgG3 antibodies

homeostasis/metabolism

abnormal B cell calcium ion homeostasis ( J:280795 )

• at both low and high dose BCR stimulation, B cells show a much higher level of calcium signaling

hematopoietic system

abnormal B cell physiology ( J:280795 )

• B-cells exhibit enhanced T-cell independent immune responses

• however, mice show no perturbation in B cell generation or maturation and show normal B cell responses to T-cell dependent antigens

increased B cell proliferation ( J:280795 )

• B cells are hyperresponsive to BCR stimulation (cross-linking of BCR by anti-IgM (Fab)2 fragments) in vitro, showing increased proliferation compared to wild-type B cells

abnormal B cell calcium ion homeostasis ( J:280795 )

• at both low and high dose BCR stimulation, B cells show a much higher level of calcium signaling

increased IgG3 level ( J:280795 )

• mice immunized with the T-cell independent type I antigen NP-Ficoll secrete greater amounts of antigen-specific IgM and IgG3 antibodies

increased IgM level ( J:280795 )

• increase in IgM antibodies in sera

• however, levels of other Ig classes are similar to wild-type mice

• mice immunized with the T-cell independent type I antigen NP-LPS secrete greater amounts of antigen-specific IgM antibodies

• mice immunized with the T-cell independent type I antigen NP-Ficoll secrete greater amounts of antigen-specific IgM and IgG3 antibodies

cellular

increased B cell proliferation ( J:280795 )

• B cells are hyperresponsive to BCR stimulation (cross-linking of BCR by anti-IgM (Fab)2 fragments) in vitro, showing increased proliferation compared to wild-type B cells