All Phenotypes Marveld1<tm1.1Liy> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Marveld1^tm1.1Liy
targeted mutation 1.1, Yu Li
MGI:6377090

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Marveld1^tm1.1Liy/Marveld1^tm1.1Liy Tg(Nes-cre)1Kln/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:6377095
cn2	Marveld1^tm1.1Liy/Marveld1^tm1.1Liy Tg(GFAP-cre)25Mes/0	involves: C57BL/6J * FVB/N	MGI:6377096

Allelic Composition	Marveld1^tm1.1Liy/Marveld1^tm1.1Liy Tg(Nes-cre)1Kln/0
Genetic Background	involves: C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Marveld1^tm1.1Liy mutation (0 available); any Marveld1 mutation (4 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule cell migration ( J:279065 )

• accumulation of granule cells in the EGL of mice at 4 weeks of age

abnormal Purkinje cell morphology ( J:279065 )

• shrinking cell bodies in the cerebellum

abnormal Purkinje cell dendrite morphology ( J:279065 )

• dramatic reduction in the apical dendritic arbor

abnormal CNS glial cell morphology ( J:279065 )

• glial scaffolds are severely disorganized and the fiber density is reduced in the cerebellum

• fibers are also tiny and disarranged lacking connection with the basement membrane in the cerebellum

cellular

abnormal cerebellar granule cell migration ( J:279065 )

• accumulation of granule cells in the EGL of mice at 4 weeks of age

Allelic Composition	Marveld1^tm1.1Liy/Marveld1^tm1.1Liy Tg(GFAP-cre)25Mes/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Marveld1^tm1.1Liy mutation (0 available); any Marveld1 mutation (4 available)
Tg(GFAP-cre)25Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar granule cell migration ( J:279065 )

• granule cells accumulate on the molecular layer

abnormal cerebellar Purkinje cell layer ( J:279065 )

• irregular at 6 days of age

abnormal Purkinje cell dendrite morphology ( J:279065 )

• apical dendritic arbors are abnormal and unable to anchor in the basement membrane

abnormal CNS glial cell morphology ( J:279065 )

• absence of strong glial fibers in mice at 6 days of age

cellular

abnormal cerebellar granule cell migration ( J:279065 )

• granule cells accumulate on the molecular layer

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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