All Phenotypes Marveld1<tm1.2Liy> MGI Mouse

impaired spatial learning ( J:279065 )

• increased latency to find the platform and spend less time crossing the platform at 6-8 weeks and 10 months of age

impaired coordination ( J:279065 )

• shorter latency to fall off a rotarod at 6-8 weeks and 10 months of age

impaired swimming ( J:279065 )

• slower swimming velocity

abnormal posture ( J:279065 )

• swing posture on a treadmill

abnormal locomotor activation ( J:279065 )

• slower running speed on a treadmill

abnormal gait ( J:279065 )

• at 6-8 weeks and 10 months of age

short stride length ( J:279065 )

• at 6-8 weeks and 10 months of age

increased thermal nociceptive threshold ( J:279065 )

• increased paw withdrawal latency in a radiant heat assay at 6-8 weeks and 10 months of age

increased neuron apoptosis ( J:279065 )

• increase in the number of apoptotic cerebral cortical cells

• apoptosis in cerebral cortex neurons, cerebellar granule cells, and basket cells at 4 weeks of age

abnormal neuronal migration ( J:279065 )

• disordered placement of neuroendocrine cells in the cerebral cortex, accumulation of cells in the molecular layer and misplaced granule cells indicate a defect in neuron migration and maturation

abnormal cerebellar granule cell migration ( J:279065 )

• many migrating granule cells are seen in mice at 6 days of age indicative of impaired inward radial migration

• increase in the number of BrdU+ cells in the internal granule layer but a similar number of BrdU+ cells overall, indicating increased cell migration in 6 day old mice

thin external granule cell layer ( J:279065 )

• at 6 days of age

abnormal stratification in cerebral cortex ( J:279065 )

• disorganized

abnormal cerebellar layer morphology ( J:279065 )

• absence of a clear boundary between the external granule layer and the Purkinje cell layer in neonatal mice

abnormal cerebellar Purkinje cell layer ( J:279065 )

• Purkinje cells in the layer are disorganized and aligned to the inner granule layer at 6 days of age

• decreased width of the layer in mice at 6 days of age

abnormal Bergmann glial cell morphology ( J:279065 )

• Bergmann glial cells are interspersed among the Purkinje and granule cells rather than forming a layer as in wild-type mice

abnormal Purkinje cell morphology ( J:279065 )

• immature Purkinje cells are seen in 4 week old mice

Purkinje cell degeneration ( J:279065 )

• notable atrophy in the cerebellum

abnormal Purkinje cell dendrite morphology ( J:279065 )

• dendrites are sparse and shorter compared to wild-type controls

abnormal CNS glial cell morphology ( J:279065 )

• glial fibers are sparse in 4 week old mice

abnormal dendrite morphology ( J:279065 )

• dendrites in the cerebral cortex are slender and disordered compared to wild-type controls

decreased neuron number ( J:279065 )

• fewer neurons with a diameter greater than 10 um, especially in layers II, IV, and V

abnormal synapse morphology ( J:279065 )

• decrease in the number of synapses and synapse structure is abnormal in the cerebral cortex of old mice

neuron degeneration ( J:279065 )

• numerous degenerating neurons are found in the cerebrum and cerebellum at 10 months of age