Phenotypes associated with this allele

• Allele Symbol: Dhx8^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6377202
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dhx8^em1(IMPC)Mbp/Dhx8^em1(IMPC)Mbp	C57BL/6NCrl-Dhx8^em1(IMPC)Mbp/Mmucd	MGI:6480439
ht2	Dhx8^em1(IMPC)Mbp/Dhx8^+	C57BL/6NCrl-Dhx8^em1(IMPC)Mbp/Mmucd	MGI:6492801

Genotype
MGI:6480439

hm1

• Allelic Composition: Dhx8^em1(IMPC)Mbp/Dhx8^em1(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Dhx8^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Dhx8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dhx8^em1(IMPC)Mbp/Dhx8^em1(IMPC)Mbp mice exhibit embryonic lethality, with some embryos recovered at E3.5 as blastocysts but no embryos detected at E7.5. Blastocysts grown in vitro hatch from the zona pellucida but form irregular outgrowths with poorly defined inner cell mass.

embryo

abnormal inner cell mass morphology ( J:279207 )

• in vitro outgrowth assays show a poorly defined ICM colony after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - UCD

embryonic lethality before implantation, incomplete penetrance ( J:279207 )

• early blastocysts are present in lower than expected Mendelian ratios at E3.5 (3% versus 25%, n=31)

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• no homozygous embryos or excess resorption sites are observed at E7.5

reproductive system

abnormal embryo implantation ( J:279207 )

• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture

Genotype
MGI:6492801

ht2

• Allelic Composition: Dhx8^em1(IMPC)Mbp/Dhx8⁺
• Genetic Background: C57BL/6NCrl-Dhx8^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Dhx8

endocrine/exocrine glands

enlarged thymus ( J:211773 )

♀

IMPC - UCD

abnormal ovary morphology ( J:211773 )

♀

IMPC - UCD

growth/size/body

enlarged kidney ( J:211773 )

♂

IMPC - UCD

hematopoietic system

enlarged thymus ( J:211773 )

♀

IMPC - UCD

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

immune system

enlarged thymus ( J:211773 )

♀

IMPC - UCD

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

IMPC - UCD

nervous system

decreased prepulse inhibition ( J:211773 )

♂

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

IMPC - UCD

enlarged kidney ( J:211773 )

♂

IMPC - UCD

small kidney ( J:211773 )

♀

IMPC - UCD

reproductive system

abnormal ovary morphology ( J:211773 )

♀

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

♀

IMPC - UCD

microphthalmia ( J:211773 )

♀

IMPC - UCD

abnormal retina morphology ( J:211773 )

♀

IMPC - UCD

abnormal vitreous body morphology ( J:211773 )

IMPC - UCD