Phenotypes associated with this allele

• Allele Symbol: Tsen54^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6377433
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tsen54^em1(IMPC)J/Tsen54^em1(IMPC)J	C57BL/6NJ-Tsen54^em1(IMPC)J/Mmjax	MGI:6493171
ht2	Tsen54^em1(IMPC)J/Tsen54^+	C57BL/6NJ-Tsen54^em1(IMPC)J/Mmjax	MGI:6772050

Genotype
MGI:6493171

hm1

• Allelic Composition: Tsen54^em1(IMPC)J/Tsen54^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Tsen54^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Tsen54

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tsen54^em1(IMPC)J/Tsen54^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as morulae but not at E7.5. Mutants fail to hatch from the zona pellucida and are dead after 72 hr in vitro outgrowth culture.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that embryos fail to hatch from the zona pellucida and are dead after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• morula-like embryos are present in normal Mendelian ratios at E3.5; no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

Genotype
MGI:6772050

ht2

• Allelic Composition: Tsen54^em1(IMPC)J/Tsen54⁺
• Genetic Background: C57BL/6NJ-Tsen54^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Tsen54

behavior/neurological

increased grip strength ( J:211773 )

♀

IMPC - JAX