Phenotypes associated with this allele

• Allele Symbol: Best1^tm2.1Web
• Allele Name: targeted mutation 2.1, Bernhard H F Weber
• Allele ID: MGI:6378540
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Best1^tm2.1Web/Best1^tm2.1Web	B6.129S1(Cg)-Best1^tm2.1Web	MGI:6378557
hm2	Best1^tm2.1Web/Best1^tm2.1Web	involves: 129S1/Sv * CD-1	MGI:6378558

Genotype
MGI:6378557

hm1

• Allelic Composition: Best1^tm2.1Web/Best1^tm2.1Web
• Genetic Background: B6.129S1(Cg)-Best1^tm2.1Web

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:280642 )

N • mice show no significant ocular abnormalities up to 2 years age, showing normal retinal histology, retinal function and visual acuity and normal retinal pigment epithelium phagocytosis

reproductive system

reproductive system phenotype ( J:280642 )

N • Background Sensitivity: total motility of sperm on the congenic C57BL/6 background is unaffected unlike on a CD-1 background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	vitelliform macular dystrophy	DOID:0050661	OMIM:153700 OMIM:153840 OMIM:608161 OMIM:616151 OMIM:616152	J:280642

Genotype
MGI:6378558

hm2

• Allelic Composition: Best1^tm2.1Web/Best1^tm2.1Web
• Genetic Background: involves: 129S1/Sv * CD-1

cellular

asthenozoospermia ( J:280642 )

♂ • Background Sensitivity: mice show a lower percentage of motile sperm on the CD-1 background but not on a congenic C57BL/6 background

reproductive system

asthenozoospermia ( J:280642 )

♂ • Background Sensitivity: mice show a lower percentage of motile sperm on the CD-1 background but not on a congenic C57BL/6 background

impaired fertilization ( J:280642 )

• Background Sensitivity: lower fertilization rates are seen when wild-type oocytes are incubated with sperm from mutant males, with 11% eggs fertilized by mutant sperm versus 36% of eggs fertilized by wild-type sperm