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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Resttm1.1Bban
targeted mutation 1.1, Botond Banfi
MGI:6378685
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Resttm1.1Bban/Rest+
Gfi1tm1(cre)Gan/Gfi1+ 		involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB/N MGI:6378689
cn2
 		Resttm1.1Bban/Rest+
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+ 		involves: 129S4/SvJaeSor * C57BL/6J MGI:6378690


Genotype
MGI:6378689
cn1
Allelic
Composition		 Resttm1.1Bban/Rest+
Gfi1tm1(cre)Gan/Gfi1+
Genetic
Background		 involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfi1tm1(cre)Gan mutation (0 available); any Gfi1 mutation (31 available)
Resttm1.1Bban mutation (0 available); any Rest mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear

nervous system




Genotype
MGI:6378690
cn2
Allelic
Composition		 Resttm1.1Bban/Rest+
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
Resttm1.1Bban mutation (0 available); any Rest mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
cochlear hair cell degeneration ( J:265659 )
• tamoxifen-injected mice show partial loss of hair cells
• organ of Corti cultures from P5 mice incubated with tamoxifen and treated with the HDAC inhibitors FK228 or SAHA show prevention of the tamoxifen-dependent degeneration of inner hair cells and outer hair cells
• treatment of P7-P9 tamoxifen-injected mice with SAHA fromP7 to P15 reduces the extent of tamoxifen-dependent hair cell loss in cochleas
increased or absent threshold for auditory brainstem response ( J:265659 )
• in P70-P80 mice treated with tamoxifen from P40 to P47
impaired hearing ( J:265659 )
• mice treated with tamoxifen from P40 to P47 show hearing loss one month after treatment
• mice treated with tamoxifen from P7 to P9 show hearing loss at P16
• treatment of P7-P9 tamoxifen-injected mice with SAHA from P7 to P15 reduces the tamoxifen-dependent shift in hearing threshold at low sound frequencies

nervous system
cochlear hair cell degeneration ( J:265659 )
• tamoxifen-injected mice show partial loss of hair cells
• organ of Corti cultures from P5 mice incubated with tamoxifen and treated with the HDAC inhibitors FK228 or SAHA show prevention of the tamoxifen-dependent degeneration of inner hair cells and outer hair cells
• treatment of P7-P9 tamoxifen-injected mice with SAHA fromP7 to P15 reduces the extent of tamoxifen-dependent hair cell loss in cochleas




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory