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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mxra8em2Diam
endonuclease-mediated mutation 2, Michael S Diamond
MGI:6378754
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mxra8em2Diam/Mxra8em2Diam C57BL/6J-Mxra8em2Diam MGI:6378763


Genotype
MGI:6378763
hm1
Allelic
Composition		 Mxra8em2Diam/Mxra8em2Diam
Genetic
Background		 C57BL/6J-Mxra8em2Diam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mxra8em2Diam mutation (0 available); any Mxra8 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to Togaviridae infection ( J:280585 )
• mice inoculated with Chikungunya virus (CHIKV, Asian strain AF15561 or East/Central/South African strain LR 2006) subcutaneously in the feet show reduced levels of CHIKV infection compared to wild-type mice, with decreased viral titers and foot swelling
• MEFs show reduced CHIKV infection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory