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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sirt3tm1.2Auw
targeted mutation 1.2, Johan Auwerx
MGI:6378760
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Sirt3tm1.2Auw/Sirt3tm1.2Auw
Sirt5tm1Fwa/Sirt5tm1Fwa 		involves: 129S1/Sv MGI:6383811
cx2
 		Sirt3tm1.2Auw/Sirt3+
Sirt5tm1Fwa/Sirt5tm1Fwa 		involves: 129S1/Sv MGI:6383812
cx3
 		Sirt3tm1.2Auw/Sirt3tm1.2Auw
Sirt5tm1Fwa/Sirt5+ 		involves: 129S1/Sv MGI:6383813


Genotype
MGI:6383811
cx1
Allelic
Composition		 Sirt3tm1.2Auw/Sirt3tm1.2Auw
Sirt5tm1Fwa/Sirt5tm1Fwa
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt3tm1.2Auw mutation (0 available); any Sirt3 mutation (32 available)
Sirt5tm1Fwa mutation (1 available); any Sirt5 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to injury ( J:265592 )
• intermediate vulnerability to light-induced retinal degeneration compared with double heterozygotes and homozygotes




Genotype
MGI:6383812
cx2
Allelic
Composition		 Sirt3tm1.2Auw/Sirt3+
Sirt5tm1Fwa/Sirt5tm1Fwa
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt3tm1.2Auw mutation (0 available); any Sirt3 mutation (32 available)
Sirt5tm1Fwa mutation (1 available); any Sirt5 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to injury ( J:265592 )
• more vulnerable to light-induced retinal degeneration than double heterozygotes




Genotype
MGI:6383813
cx3
Allelic
Composition		 Sirt3tm1.2Auw/Sirt3tm1.2Auw
Sirt5tm1Fwa/Sirt5+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt3tm1.2Auw mutation (0 available); any Sirt3 mutation (32 available)
Sirt5tm1Fwa mutation (1 available); any Sirt5 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to injury ( J:265592 )
• intermediate vulnerability to light-induced retinal degeneration compared with double heterozygotes and homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory