Phenotypes associated with this allele

• Allele Symbol: Tubgcp2^em1(IMPC)Tcp
• Allele Name: endonuclease-mediated mutation 1, The Centre for Phenogenomics
• Allele ID: MGI:6381351
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tubgcp2^em1(IMPC)Tcp/Tubgcp2^em1(IMPC)Tcp	C57BL/6N-Tubgcp2^em1(IMPC)Tcp/Cmmr	MGI:6696960
ht2	Tubgcp2^em1(IMPC)Tcp/Tubgcp2^+	C57BL/6N-Tubgcp2^em1(IMPC)Tcp/Cmmr	MGI:6696959

Genotype
MGI:6696960

hm1

• Allelic Composition: Tubgcp2^em1(IMPC)Tcp/Tubgcp2^em1(IMPC)Tcp
• Genetic Background: C57BL/6N-Tubgcp2^em1(IMPC)Tcp/Cmmr

Data Sources

IMPC Data for Tubgcp2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tubgcp2^em1(IMPC)Tcp/Tubgcp2^em1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form outgrowths with little/no inner cell mass colony after 3 days in culture.

embryo

absent inner cell mass ( J:279207 )

• in vitro outgrowth assays show small/no ICM colony after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• early blastocysts are present in approximate Mendelian ratios at E3.5 (38% versus expected 25%, n=24); no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system

abnormal embryo implantation ( J:279207 )

• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture

Genotype
MGI:6696959

ht2

• Allelic Composition: Tubgcp2^em1(IMPC)Tcp/Tubgcp2⁺
• Genetic Background: C57BL/6N-Tubgcp2^em1(IMPC)Tcp/Cmmr

Data Sources

IMPC Data for Tubgcp2

skeleton

abnormal sternum morphology ( J:211773 )

♂

IMPC - TCP