Phenotypes associated with this allele

• Allele Symbol: Agk^tm1.1Smoc
• Allele Name: targeted mutation 1.1, Shanghai Model Organisms Center
• Allele ID: MGI:6381660
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agk^tm1.1Smoc/Agk^tm1.1Smoc	Not Specified	MGI:6382294

Genotype
MGI:6382294

hm1

• Allelic Composition: Agk^tm1.1Smoc/Agk^tm1.1Smoc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:282052 )

N • normal effector CD4-positive alpha-beta T cell number after subcutaneous injection of highly immunogenic MC38 murine colon cancer cells at age 8 weeks

N • normal effector CD4-positive alpha-beta T cell number after subcutaneous injection of highly immunogenic B16-OVA melanoma cells at age 8 weeks

N • normal effector CD4-positive alpha-beta T cell number after subcutaneous injection of low immunogenic B16-F10 melanoma cells at age 8 weeks

decreased effector memory CD8-positive, alpha-beta T cell number ( J:282052 )

• after subcutaneous injection of highly immunogenic MC38 murine colon cancer cells at age 8 weeks

• after subcutaneous injection of highly immunogenic B16-OVA melanoma cells at age 8 weeks

• after subcutaneous injection of low immunogenic B16-F10 melanoma cells at age 8 weeks

immune system

immune system phenotype ( J:282052 )

N • normal thymocyte development and peripheral T cell frequency

N • normal proportions of Ifng-producing CD4+ and CD8+ effector T cells in spleen and lymph nodes

N • normal percentages of Treg cells in thymus, spleen and lymph nodes

decreased effector memory CD8-positive, alpha-beta T cell number ( J:282052 )

• after subcutaneous injection of highly immunogenic MC38 murine colon cancer cells at age 8 weeks

• after subcutaneous injection of highly immunogenic B16-OVA melanoma cells at age 8 weeks

• after subcutaneous injection of low immunogenic B16-F10 melanoma cells at age 8 weeks

mortality/aging

premature death ( J:282052 )

• after subcutaneous injection of highly immunogenic MC38 murine colon cancer cells at age 8 weeks

neoplasm

increased tumor incidence ( J:282052 )

• increased tumor size after subcutaneous injection of highly immunogenic MC38 murine colon cancer cells at age 8 weeks

• increased tumor size after subcutaneous injection of highly immunogenic B16-OVA melanoma cells at age 8 weeks

• increased tumor size after subcutaneous injection of low immunogenic B16-F10 melanoma cells at age 8 weeks