Phenotypes associated with this allele

• Allele Symbol: Agk^em1Qiz
• Allele Name: endonuclease-mediated mutation 1, Qiang Zou
• Allele ID: MGI:6381662
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agk^em1Qiz/Agk^em1Qiz	involves: C57BL/6 * DBA/2	MGI:6382295

Genotype
MGI:6382295

hm1

• Allelic Composition: Agk^em1Qiz/Agk^em1Qiz
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:282052 )

N • normal CD4-positive alpha-beta T cell extracellular acidification and (ECAR) and oxidative phosphorylation (OXPHOS) rates, and TCR- and CD28-induced PTEN phosphorylation and PI3K-mTOR activation

abnormal CD8-positive, alpha beta T cell morphology ( J:282052 )

• substantial cell size decrease

decreased effector memory CD8-positive, alpha-beta T cell number ( J:282052 )

• after subcutaneous injection of highly immunogenic MC38 murine colon cancer cells at age 8 weeks

abnormal CD8-positive, alpha-beta T cell physiology ( J:282052 )

• lower extracellular acidification (ECAR) rate

immune system

abnormal CD8-positive, alpha beta T cell morphology ( J:282052 )

• substantial cell size decrease

decreased effector memory CD8-positive, alpha-beta T cell number ( J:282052 )

• after subcutaneous injection of highly immunogenic MC38 murine colon cancer cells at age 8 weeks

abnormal CD8-positive, alpha-beta T cell physiology ( J:282052 )

• lower extracellular acidification (ECAR) rate

mortality/aging

premature death ( J:282052 )

• after subcutaneous injection of highly immunogenic MC38 murine colon cancer cells at age 8 weeks