Phenotypes associated with this allele

• Allele Symbol: Adm2^em1Zhan
• Allele Name: endonuclease-mediated mutation 1, Wei Zhang
• Allele ID: MGI:6382308
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adm2^em1Zhan/Adm2^em1Zhan	Not Specified	MGI:6382309

Genotype
MGI:6382309

hm1

• Allelic Composition: Adm2^em1Zhan/Adm2^em1Zhan
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased Ly6C high monocyte number ( J:266495 )

• monocyte progenitors (Ly6C^high CX3CR+) in the bone marrow expressing a high level of CCR2 are increased

cardiovascular system

increased vascular permeability ( J:266495 )

• mice show an increase in the basal vascular leakage

• VEGF induces more severe vascular leakage than in wild-type mice

• systemic administration of a mature form of ADM2 called IMD40 reduces the vascular leakage

• however, mice appear healthy

liver/biliary system

liver inflammation ( J:266495 )

• macrophage infiltration is increased in the liver

cellular

increased cell chemotaxis ( J:266495 )

• migration of bone marrow monocytes and progenitors towards MCP-1 in a chemotaxis assay is increased

homeostasis/metabolism

abnormal susceptibility to injury induced morbidity/mortality ( J:266495 )

• only 8.3% of mice survive 15 days after cecal ligation and puncture (CLP) surgery (to induce sepsis) compared to 75% of wild-type mice

• treatment with a mature form of ADM2 called IMD40, improves the survival rate of septic mutant mice to 83%

increased susceptibility to injury ( J:266495 )

• mice subjected to cecal ligation and puncture (CLP) surgery to induce sepsis show more severe lung edema and kidney injury, more severe brush border shrinkage, greater number of infiltrating macrophages in the liver and lungs and decreased survival than wild-type mice

immune system

increased Ly6C high monocyte number ( J:266495 )

• monocyte progenitors (Ly6C^high CX3CR+) in the bone marrow expressing a high level of CCR2 are increased

increased inflammatory response ( J:266495 )

• lungs and kidneys show spontaneous perivascular cuffing and vacuole degeneration

• mice undergoing CLP surgery to induce sepsis show a greater number of infiltrating macrophages in the liver and lungs than wild-type mice

liver inflammation ( J:266495 )

• macrophage infiltration is increased in the liver

increased susceptibility to infection ( J:266495 )

• mice undergoing cecal ligation and puncture (CLP) surgery to induce sepsis are more susceptible to sepsis than wild-type mice, with only 8.3% of mice surviving 15 days after surgery compared to 75% of wild-type mice

• however, microbial clearance in the circulation is not different from wild-type mice

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:266495 )

• only 8.3% of mice survive 15 days after cecal ligation and puncture (CLP) surgery (to induce sepsis) compared to 75% of wild-type mice

• treatment with a mature form of ADM2 called IMD40, improves the survival rate of septic mutant mice to 83%

renal/urinary system

abnormal kidney morphology ( J:266495 )

• kidneys show spontaneous perivascular cuffing and vacuole degeneration

• mice undergoing CLP surgery show increased vacuole degeneration of tubular epithelial cells

abnormal proximal convoluted tubule brush border morphology ( J:266495 )

• mice show shrinkage of the brush border

• mice subjected to CLP surgery show more severe brush border shrinkage than wild-type mice

respiratory system

abnormal lung morphology ( J:266495 )

• lungs show spontaneous perivascular cuffing and vacuole degeneration and pathogenic changes in the endothelial barrier