Phenotypes associated with this allele

• Allele Symbol: Kcnv2^{tm1.2(KOMP)Wtsi}
• Allele Name: targeted mutation 1.2, Wellcome Trust Sanger Institute
• Allele ID: MGI:6382425
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcnv2^tm1.2(KOMP)Wtsi/Kcnv2^tm1.2(KOMP)Wtsi	involves: 129S6/SvEvTac * C57BL/6N	MGI:6383044
cx2	Kcnb1^tm1Dgen/Kcnb1^tm1Dgen Kcnv2^tm1.2(KOMP)Wtsi/Kcnv2^tm1.2(KOMP)Wtsi	involves: 129S6/SvEvTac * C57BL/6N	MGI:6383045

Genotype
MGI:6383044

hm1

• Allelic Composition: Kcnv2^{tm1.2(KOMP)Wtsi}/Kcnv2^{tm1.2(KOMP)Wtsi}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

increased retina apoptosis ( J:279816 )

• at 1, 3 and 6 months of age

• however, levels are reduced in older aged mice as in wild-type mice

decreased retina rod cell number ( J:279816 )

short photoreceptor inner segment ( J:279816 )

short photoreceptor outer segment ( J:279816 )

thin retina outer nuclear layer ( J:279816 )

decreased total retina thickness ( J:279816 )

• due to reduced photoreceptor layers

abnormal cone electrophysiology ( J:279816 )

• reduced flicker amplitude without major delay

abnormal rod electrophysiology ( J:279816 )

• barely discernable a-wave with altered shape, elevated b-wave, c-wave is completely absent

• altered amplitudes of oscillatory potentials (reduced OP1 and OP2; increased OP3 and OP4)

cellular

increased retina apoptosis ( J:279816 )

• at 1, 3 and 6 months of age

• however, levels are reduced in older aged mice as in wild-type mice

nervous system

decreased retina rod cell number ( J:279816 )

short photoreceptor inner segment ( J:279816 )

short photoreceptor outer segment ( J:279816 )

Genotype
MGI:6383045

cx2

• Allelic Composition: Kcnb1^tm1Dgen/Kcnb1^tm1Dgen; Kcnv2^{tm1.2(KOMP)Wtsi}/Kcnv2^{tm1.2(KOMP)Wtsi}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

vision/eye

short photoreceptor inner segment ( J:279816 )

short photoreceptor outer segment ( J:279816 )

thin retina outer nuclear layer ( J:279816 )

decreased total retina thickness ( J:279816 )

• due to reduced photoreceptor layers

abnormal cone electrophysiology ( J:279816 )

• reduced flicker amplitude without major delay

abnormal rod electrophysiology ( J:279816 )

• barely discernable a-wave with altered shape, c-wave is completely absent

• altered amplitudes of oscillatory potentials (reduced OP1 and OP2; increased OP3 and OP4)

nervous system

short photoreceptor inner segment ( J:279816 )

short photoreceptor outer segment ( J:279816 )