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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hellstm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6382883
Summary 1 genotype


Genotype
MGI:6389564
cn1
Allelic
Composition		 Hellstm1c(EUCOMM)Wtsi/Hellstm1d(EUCOMM)Wtsi
Tg(Stra8-icre)1Reb/0
Genetic
Background		 (B6(Cg)-Hellstm1c(EUCOMM)Wtsi/BakrJ x B6.Cg-Hellstm1d(EUCOMM)Wtsi Tg(Stra8-icre)1Reb/Bakr)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hellstm1c(EUCOMM)Wtsi mutation (1 available); any Hells mutation (58 available)
Hellstm1d(EUCOMM)Wtsi mutation (0 available); any Hells mutation (58 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal meiosis ( J:283594 )
• Incomplete DNA repair at double stranded breaks in pachytene spermatocytes and the genomic locations of the double stranded breaks is abnormal
arrest of male meiosis ( J:283594 )
• arrest at the late-zygotene to early pachytene stage, with an increased proportion of leptotene and zygotene and absence of normal pachytene and diplotene spermatocytes, with the pachytene cells having H2AX phosphorylation and incomplete synapsis
abnormal DNA methylation during gametogenesis ( J:283594 )
• At 12 days of age spermatocytes show a decrease in epigenomic modification at recombination hotspots, H3K4me3 and chromatin accessibility sites at recombination hotspots are decreased

endocrine/exocrine glands

reproductive system
abnormal meiosis ( J:283594 )
• Incomplete DNA repair at double stranded breaks in pachytene spermatocytes and the genomic locations of the double stranded breaks is abnormal
arrest of male meiosis ( J:283594 )
• arrest at the late-zygotene to early pachytene stage, with an increased proportion of leptotene and zygotene and absence of normal pachytene and diplotene spermatocytes, with the pachytene cells having H2AX phosphorylation and incomplete synapsis
abnormal DNA methylation during gametogenesis ( J:283594 )
• At 12 days of age spermatocytes show a decrease in epigenomic modification at recombination hotspots, H3K4me3 and chromatin accessibility sites at recombination hotspots are decreased
male infertility ( J:283594 )
• these males fail to sire offspring




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory