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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Scfd1em1(IMPC)Tcp
endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI:6383384
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Scfd1em1(IMPC)Tcp/Scfd1em1(IMPC)Tcp C57BL/6N-Scfd1em1(IMPC)Tcp/Cmmr MGI:6493078
ht2
 		Scfd1em1(IMPC)Tcp/Scfd1+ C57BL/6N-Scfd1em1(IMPC)Tcp/Cmmr MGI:6696888


Genotype
MGI:6493078
hm1
Allelic
Composition		 Scfd1em1(IMPC)Tcp/Scfd1em1(IMPC)Tcp
Genetic
Background		 C57BL/6N-Scfd1em1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scfd1em1(IMPC)Tcp mutation (2 available); any Scfd1 mutation (34 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Scfd1em1(IMPC)Tcp/Scfd1em1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. In vitro, some blastocysts fail to hatch from the zona pellucida and do not form outgrowths while others do hatch but form outgrowths with no inner cell mass and dispersed trophectoderm.

embryo
failure of blastocyst to hatch from the zona pellucida ( J:279207 )
• in vitro outgrowth assays show that some blastocysts fail to hatch from the zona pellucida after 3 days in culture
absent inner cell mass ( J:279207 )
• in vitro, some blastocysts do hatch from the zona but form outgrowths with no apparent inner cell mass (ICM) after 3 days in culture
abnormal trophectoderm morphology ( J:279207 )
• in vitro, blastocysts that do hatch form outgrowths with no apparent ICM and dispersed trophectoderm (TE) after 3 days in culture

mortality/aging
embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )
• although blastocyst-like embryos are present in expected Mendelian ratios at E3.5, no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system
failure of embryo implantation ( J:279207 )
• in vitro, some blastocysts fail to hatch and do not form outgrowths after 3 days in culture




Genotype
MGI:6696888
ht2
Allelic
Composition		 Scfd1em1(IMPC)Tcp/Scfd1+
Genetic
Background		 C57BL/6N-Scfd1em1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scfd1em1(IMPC)Tcp mutation (2 available); any Scfd1 mutation (34 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

integument




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory