Analysis Tools
reproductive system
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• less frequent estrus
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• with irregular reproductive cycle
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• reduced productive matings, number of litters, and litter size
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• smaller and fewer liters with increased litter interval
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nervous system
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• Th+ ARC neurons exhibit reduced interburst intervals and enhanced instantaneous burst frequencies, increased variability of Vu and reduced burst strength causing a reduction in both depolarization envelope and spike frequency within a burst compared with wild-type cells
• Th+ ARC neurons exhibit loss of prolactin-evoked tonic excitation unlike wild-type mice
• however, rhythmic activity in the presence of prolactin remains intake
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homeostasis/metabolism
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• some female mice exhibit delayed luteinizing hormone peaks compared with wild-type mice
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• however, female mice exhibit prolactin surges
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