Analysis Tools
vision/eye
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• moderate cell loss is seen in the inner retinal layers at 16 months of age
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• mice exhibit progressive loss of photoreceptors at older ages, with most photoresceptors lost by 16 months of age
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• outer nuclear layer is reduced to one or two rows or is completely absent at 16 months of age
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• mice exhibit similar reductions in retinal thickness at 1, 2, and 6 weeks of age as single Irs2tm1Mfw homozygotes
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nervous system
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• mice exhibit progressive loss of photoreceptors at older ages, with most photoresceptors lost by 16 months of age
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