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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Plgrkttm1Lmls
targeted mutation 1, Lindsey Miles
MGI:6384265
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Plgrkttm1Lmls/Plgrkttm1Lmls B6.Cg-Plgrkttm1Lmls MGI:6384648
ht2
Plgrkttm1Lmls/Plgrkt+ B6.Cg-Plgrkttm1Lmls MGI:6384649


Genotype
MGI:6384648
hm1
Allelic
Composition
Plgrkttm1Lmls/Plgrkttm1Lmls
Genetic
Background
B6.Cg-Plgrkttm1Lmls
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plgrkttm1Lmls mutation (1 available); any Plgrkt mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after 72 hrs following treatment with 4% thioglycolate, mice exhibit reduced leukocyte and macrophage recruitment compared with wild-type mice
• however, resident peritoneal cell levels are normal
• reduced plasminogen binding capacity
• following treatment with 4% thioglycolate
• however, resident peritoneal cell levels are normal
• 4-fold compared to controls starting at 4 months

integument
• 4-fold compared to controls starting at 4 months

growth/size/body
• in female, but not male, mice

cellular
• following treatment with 4% thioglycolate
• however, resident peritoneal cell levels are normal
• after 72 hrs following treatment with 4% thioglycolate, mice exhibit reduced leukocyte and macrophage recruitment compared with wild-type mice
• however, resident peritoneal cell levels are normal
• no pups from homozygous mice survive to weaning with no milk in the stomachs of the pups

endocrine/exocrine glands

hematopoietic system
• after 72 hrs following treatment with 4% thioglycolate, mice exhibit reduced leukocyte and macrophage recruitment compared with wild-type mice
• however, resident peritoneal cell levels are normal
• reduced plasminogen binding capacity
• following treatment with 4% thioglycolate
• however, resident peritoneal cell levels are normal




Genotype
MGI:6384649
ht2
Allelic
Composition
Plgrkttm1Lmls/Plgrkt+
Genetic
Background
B6.Cg-Plgrkttm1Lmls
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plgrkttm1Lmls mutation (1 available); any Plgrkt mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 2-fold compared to controls

integument
• 2-fold compared to controls





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory