Phenotypes associated with this allele

• Allele Symbol: Tbcd^em1(IMPC)Bay
• Allele Name: endonuclease-mediated mutation 1, Baylor College of Medicine
• Allele ID: MGI:6384595
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbcd^em1(IMPC)Bay/Tbcd^em1(IMPC)Bay	C57BL/6NJ-Tbcd^em1(IMPC)Bay/Mmnc	MGI:7716758
hm2	Tbcd^em1(IMPC)Bay/Tbcd^em1(IMPC)Bay	C57BL/6N-Tbcd^em1(IMPC)Bay/BayMmucd	MGI:6731454

Genotype
MGI:7716758

hm1

• Allelic Composition: Tbcd^em1(IMPC)Bay/Tbcd^em1(IMPC)Bay
• Genetic Background: C57BL/6NJ-Tbcd^em1(IMPC)Bay/Mmnc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tbcd^em1(IMPC)Bay/Tbcd^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts in vitro hatch from the zona pellucida and form normal outgrowths with apparent inner cell mass and trophectoderm/primitive endoderm cells.

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• blastocysts are recovered at E3.5 (16% versus expected 25%, n=32); no homozygous embryos are recovered at E7.5 but excess resorption sites suggest that embryos elicit a decidual response in vivo

• in vitro, blastocysts hatch from the zona pellucida and form normal outgrowths with apparent inner cell mass (ICM) and trophectoderm (TE) and primitive endoderm (PrE) cells after 3 days in culture

Genotype
MGI:6731454

hm2

• Allelic Composition: Tbcd^em1(IMPC)Bay/Tbcd^em1(IMPC)Bay
• Genetic Background: C57BL/6N-Tbcd^em1(IMPC)Bay/BayMmucd

Data Sources

IMPC Data for Tbcd

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM