Phenotypes associated with this allele

• Allele Symbol: Ms4a6d^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:6384846
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ms4a6d^em1Cya/Ms4a6d^em1Cya	involves: C57BL/6	MGI:7618340

Genotype
MGI:7618340

hm1

• Allelic Composition: Ms4a6d^em1Cya/Ms4a6d^em1Cya
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to endotoxin shock ( J:342776 )

• mice intraperitoneally injected with one dose of LPS exhibit a survival advantage against endotoxin lethality, with over 30% of mice remaining alive at 72 hours compared to 100% lethality of wild-type mice within 54 hours after LPS injection

• LPS-treated mice exhibit higher body temperatures, lower composite clinical scores, and lower expression of proinflammatory cytokines TNF-alpha and proIL-1beta in peritoneal CD45+F4/80+CD11b+ macrophages and lower serum levels of these cytokines at 3 and 6 hours of LPS administration

• LPS-primed bone marrow-derived macrophages exhibit lower concentrations of profinflammatory proIL-1beta, IL-6, and TNF-alpha cytokines and show attenuation of the oxygen consumption rate (OCR, as measured by maximal respiration), ATP-leaked respiration, and the separate respiration capacity

• mice show attenuated secretion of proinflammatory mitochondrial reactive oxygen species (mtROS) following LPS treatment

• however, mice exhibit normal macrophage development and normal T cell development in the thymus and spleen