nervous system
• cell-autonomous increased neurogenesis following injection of a cre-expressing adenovirus into lateral ventricles at E13.5
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Allele Symbol Allele Name Allele ID |
Gm30731tm1.1Dalm targeted mutation 1.1, Daniel A Lim MGI:6385064 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• cell-autonomous increased neurogenesis following injection of a cre-expressing adenovirus into lateral ventricles at E13.5
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• altered postnatal cortical lamination
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• of CTIP2+neurons in the cortical plate at E13.5
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• reduced proliferation of ventricular zone cells at E13.5
• fewer neurons born at E15.5 and P14 in the cortex with reduced BrdU+;CUX1+ cells in the upper layers
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• increased neurogenesis of ventricular-subventricular zone neural stem cell cultures treated with tamoxifen with 6-fold more neurons
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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