Phenotypes associated with this allele

• Allele Symbol: Casp8^{em1(IMPC)Ccpcz}
• Allele Name: endonuclease-mediated mutation 1, Institute of Molecular Genetics
• Allele ID: MGI:6385274
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Casp8^em1(IMPC)Ccpcz/Casp8^em1(IMPC)Ccpcz	C57BL/6NCrl-Casp8^em1(IMPC)Ccpcz/Ccpcz	MGI:7628927
ht2	Casp8^em1(IMPC)Ccpcz/Casp8^+	C57BL/6NCrl-Casp8^em1(IMPC)Ccpcz/Ccpcz	MGI:7628926

Genotype
MGI:7628927

hm1

• Allelic Composition: Casp8^{em1(IMPC)Ccpcz}/Casp8^{em1(IMPC)Ccpcz}
• Genetic Background: C57BL/6NCrl-Casp8^{em1(IMPC)Ccpcz}/Ccpcz

Data Sources

IMPC Data for Casp8

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - CCP-IMG

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - CCP-IMG

Genotype
MGI:7628926

ht2

• Allelic Composition: Casp8^{em1(IMPC)Ccpcz}/Casp8⁺
• Genetic Background: C57BL/6NCrl-Casp8^{em1(IMPC)Ccpcz}/Ccpcz

Data Sources

IMPC Data for Casp8

cardiovascular system

abnormal heart morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged heart ( J:211773 )

♂

IMPC - CCP-IMG

increased heart left ventricle size ( J:211773 )

♀

IMPC - CCP-IMG

thick ventricular wall ( J:211773 )

IMPC - CCP-IMG

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - CCP-IMG

hematopoietic system

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - CCP-IMG

immune system

decreased lymphocyte cell number ( J:211773 )

♂

IMPC - CCP-IMG

liver/biliary system

abnormal liver morphology ( J:211773 )

♀

IMPC - CCP-IMG

small liver ( J:211773 )

♀

IMPC - CCP-IMG

renal/urinary system

abnormal kidney morphology ( J:211773 )

♀

IMPC - CCP-IMG

small kidney ( J:211773 )

♀

IMPC - CCP-IMG