Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nudt21tm1.1Ejwpj targeted mutation 1.1, Eric Wagner MGI:6385854 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• bleomycin-treated mice once or repeatedly exhibit increased lung fibrosis compared with wild-type mice
• however, no increase in lethality is observed
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• increased in bleomycin-treated mice once or repeatedly
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the bronchial alveolar lavage fluid of bleomycin- and tamoxifen-treated mice once or repeatedly
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• bleomycin- and tamoxifen-treated mice exhibit increased collagen in bronchial alvealar lavage (BAL) fluid, alpha-SMA+ cells, total cell numbers (including macrophages and lymphocytes in the BAL), and exaggerated features of pulmonary fibrosis compared with wild-type mice
• however, late stage cellular inflammation and mortality are not affected
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• increased in bleomycin- and tamoxifen-treated mice once or repeatedly
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• in the early stages in the lungs of bleomycin- and tamoxifen-treated mice
• however, late stage cellular inflammation is not affected
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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