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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Arl3Gt(EUCJ0159b07)1.1Hmgu
gene trap 1.1, Helmholtz Zentrum Muenchen GmbH
MGI:6386241
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Arl3Gt(EUCJ0159b07)1.1Hmgu/Arl3Gt(EUCJ0159b07)1.1Hmgu
Tg(Rho-icre)1Ck/0
involves: C57BL/6J * C57BL/6N * SJL MGI:6386321
cn2
Arl3Gt(EUCJ0159b07)1.1Hmgu/Arl3Gt(EUCJ0159b07)1.1Hmgu
Tg(Six3-cre)69Frty/0
involves: C57BL/6N * DBA/2 MGI:6386322


Genotype
MGI:6386321
cn1
Allelic
Composition
Arl3Gt(EUCJ0159b07)1.1Hmgu/Arl3Gt(EUCJ0159b07)1.1Hmgu
Tg(Rho-icre)1Ck/0
Genetic
Background
involves: C57BL/6J * C57BL/6N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arl3Gt(EUCJ0159b07)1.1Hmgu mutation (0 available); any Arl3 mutation (27 available)
Tg(Rho-icre)1Ck mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• progressive, at P15 and further by P50
• begins to decline at 1 month
• reduced a- and b-waves at 1 month
• however, readings at P15 are normal

behavior/neurological
• extinct at 2 months
• however, optokinetic response at 1 month is normal

nervous system




Genotype
MGI:6386322
cn2
Allelic
Composition
Arl3Gt(EUCJ0159b07)1.1Hmgu/Arl3Gt(EUCJ0159b07)1.1Hmgu
Tg(Six3-cre)69Frty/0
Genetic
Background
involves: C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arl3Gt(EUCJ0159b07)1.1Hmgu mutation (0 available); any Arl3 mutation (27 available)
Tg(Six3-cre)69Frty mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• lack of ciliogenesis
• however, ciliogenesis is rescued by adenovirus expression of the protein
• absent in the central retina with a lack of ciliogenesis
• however, the outer segment is present in the retina periphery and ciliogenesis is rescued by adenovirus expression of the protein
• at 2 month with no response to light
• reduced at P15 and further at 1 month
• reduced at P15 and further at 1 month

behavior/neurological
• reduced at 1 month and nearly extinguished at 2 months

nervous system
• lack of ciliogenesis
• however, ciliogenesis is rescued by adenovirus expression of the protein
• absent in the central retina with a lack of ciliogenesis
• however, the outer segment is present in the retina periphery and ciliogenesis is rescued by adenovirus expression of the protein

cellular
• lack of ciliogenesis
• however, ciliogenesis is rescued by adenovirus expression of the protein





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory