Phenotypes associated with this allele

• Allele Symbol: Cacna2d2^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6386301
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna2d2^em1(IMPC)Mbp/Cacna2d2^em1(IMPC)Mbp	C57BL/6N-Cacna2d2^em1(IMPC)Mbp/MbpMmucd	MGI:7266982
ht2	Cacna2d2^em1(IMPC)Mbp/Cacna2d2^+	C57BL/6N-Cacna2d2^em1(IMPC)Mbp/MbpMmucd	MGI:7266981

Genotype
MGI:7266982

hm1

• Allelic Composition: Cacna2d2^em1(IMPC)Mbp/Cacna2d2^em1(IMPC)Mbp
• Genetic Background: C57BL/6N-Cacna2d2^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Cacna2d2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

tremors ( J:211773 )

♂

IMPC - UCD

abnormal gait ( J:211773 )

♂

IMPC - UCD

no spontaneous movement ( J:211773 )

IMPC - UCD

cardiovascular system

abnormal heart morphology ( J:211773 )

♂

IMPC - UCD

small heart ( J:211773 )

♂

IMPC - UCD

embryo

abnormal placenta morphology ( J:211773 )

♂

IMPC - UCD

endocrine/exocrine glands

abnormal seminal vesicle morphology ( J:211773 )

♂

IMPC - UCD

small seminal vesicle ( J:211773 )

♂

IMPC - UCD

hematopoietic system

abnormal spleen morphology ( J:211773 )

♂

IMPC - UCD

small spleen ( J:211773 )

♂

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

♂

IMPC - UCD

small spleen ( J:211773 )

♂

IMPC - UCD

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - UCD

reproductive system

abnormal seminal vesicle morphology ( J:211773 )

♂

IMPC - UCD

small seminal vesicle ( J:211773 )

♂

IMPC - UCD

female infertility ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:7266981

ht2

• Allelic Composition: Cacna2d2^em1(IMPC)Mbp/Cacna2d2⁺
• Genetic Background: C57BL/6N-Cacna2d2^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Cacna2d2

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - UCD

behavior/neurological

no spontaneous movement ( J:211773 )

IMPC - UCD

endocrine/exocrine glands

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

enlarged testis ( J:211773 )

♂

IMPC - UCD

growth/size/body

increased lean body mass ( J:211773 )

♂

IMPC - UCD

enlarged kidney ( J:211773 )

♂

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

increased spleen weight ( J:211773 )

♂

IMPC - UCD

hematopoietic system

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

increased spleen weight ( J:211773 )

♂

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

IMPC - UCD

enlarged spleen ( J:211773 )

IMPC - UCD

increased spleen weight ( J:211773 )

♂

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

♂

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

IMPC - UCD

enlarged kidney ( J:211773 )

♂

IMPC - UCD

small kidney ( J:211773 )

♀

IMPC - UCD

reproductive system

abnormal testis morphology ( J:211773 )

♂

IMPC - UCD

enlarged testis ( J:211773 )

♂

IMPC - UCD

vision/eye

cataract ( J:211773 )

♀

IMPC - UCD

abnormal vitreous body morphology ( J:211773 )

♀

IMPC - UCD

persistence of hyaloid vascular system ( J:211773 )

IMPC - UCD