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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cacna2d2em1(IMPC)Mbp
endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
MGI:6386301
Summary 2 genotypes


Genotype
MGI:7266982
hm1
Allelic
Composition		 Cacna2d2em1(IMPC)Mbp/Cacna2d2em1(IMPC)Mbp
Genetic
Background		 C57BL/6N-Cacna2d2em1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna2d2em1(IMPC)Mbp mutation (1 available); any Cacna2d2 mutation (72 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
tremors ( J:211773 )
IMPC - UCD
abnormal gait ( J:211773 )
IMPC - UCD

cardiovascular system
small heart ( J:211773 )
IMPC - UCD

embryo

endocrine/exocrine glands

hematopoietic system
small spleen ( J:211773 )
IMPC - UCD

immune system
small spleen ( J:211773 )
IMPC - UCD

mortality/aging

reproductive system




Genotype
MGI:7266981
ht2
Allelic
Composition		 Cacna2d2em1(IMPC)Mbp/Cacna2d2+
Genetic
Background		 C57BL/6N-Cacna2d2em1(IMPC)Mbp/MbpMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna2d2em1(IMPC)Mbp mutation (1 available); any Cacna2d2 mutation (72 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue

behavior/neurological

endocrine/exocrine glands

growth/size/body
increased lean body mass ( J:211773 )
IMPC - UCD
enlarged kidney ( J:211773 )
IMPC - UCD
enlarged spleen ( J:211773 )
IMPC - UCD
increased spleen weight ( J:211773 )
IMPC - UCD

hematopoietic system
enlarged spleen ( J:211773 )
IMPC - UCD

immune system
enlarged spleen ( J:211773 )
IMPC - UCD

integument

renal/urinary system
enlarged kidney ( J:211773 )
IMPC - UCD
small kidney ( J:211773 )
IMPC - UCD

reproductive system

vision/eye
cataract ( J:211773 )
IMPC - UCD




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory