Phenotypes associated with this allele

• Allele Symbol: Ttc1^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6386313
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ttc1^em1(IMPC)Mbp/Ttc1^em1(IMPC)Mbp	C57BL/6NCrl-Ttc1^em1(IMPC)Mbp/Mmucd	MGI:6493174
ht2	Ttc1^em1(IMPC)Mbp/Ttc1^+	C57BL/6NCrl-Ttc1^em1(IMPC)Mbp/Mmucd	MGI:6696955

Genotype
MGI:6493174

hm1

• Allelic Composition: Ttc1^em1(IMPC)Mbp/Ttc1^em1(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Ttc1^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Ttc1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ttc1^em1(IMPC)Mbp/Ttc1^em1(IMPC)Mbp mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form irregular outgrowths with poorly defined inner cell mass colony.

embryo

abnormal inner cell mass morphology ( J:279207 )

• in vitro outgrowth assays show a poorly defined ICM colony after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - UCD

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• blastocysts are present in expected Mendelian ratios at E3.5; no homozygous embryos are recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system

abnormal embryo implantation ( J:279207 )

• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture

Genotype
MGI:6696955

ht2

• Allelic Composition: Ttc1^em1(IMPC)Mbp/Ttc1⁺
• Genetic Background: C57BL/6NCrl-Ttc1^em1(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Ttc1

embryo

abnormal placenta morphology ( J:211773 )

IMPC - UCD

renal/urinary system

urinary bladder obstruction ( J:211773 )

♂

IMPC - UCD