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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox9em1(cre/ERT2)Tchn
endonuclease-mediated mutation 1, Ting Chen
MGI:6386787
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sox9em1(cre/ERT2)Tchn/Sox9+
Stk26tm2.1Zzh/Stk26tm2.1Zzh 		involves: 129P2/OlaHsd * C57BL/6 MGI:7491701
cn2
 		Ctnnb1tm1.1Smoc/Ctnnb1tm1.1Smoc
Sox9em1(cre/ERT2)Tchn/Sox9+ 		involves: C57BL/6 MGI:7491703
cn3
 		Sox9em1(cre/ERT2)Tchn/Sox9+
Stk26tm2.1Zzh/Stk26tm2.1Zzh 		involves: C57BL/6 * SJL MGI:7491702


Genotype
MGI:7491701
cn1
Allelic
Composition		 Sox9em1(cre/ERT2)Tchn/Sox9+
Stk26tm2.1Zzh/Stk26tm2.1Zzh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9em1(cre/ERT2)Tchn mutation (1 available); any Sox9 mutation (33 available)
Stk26tm2.1Zzh mutation (0 available); any Stk26 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal enterocyte proliferation ( J:322311 )
• reduced number of intestinal stem cells and proliferation of intestinal cells

digestive/alimentary system
abnormal enterocyte proliferation ( J:322311 )
• reduced number of intestinal stem cells and proliferation of intestinal cells

homeostasis/metabolism
decreased incidence of tumors by chemical induction ( J:322311 )
• reduced number of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal adenocarcinomas

neoplasm
decreased incidence of tumors by chemical induction ( J:322311 )
• reduced number of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal adenocarcinomas




Genotype
MGI:7491703
cn2
Allelic
Composition		 Ctnnb1tm1.1Smoc/Ctnnb1tm1.1Smoc
Sox9em1(cre/ERT2)Tchn/Sox9+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1.1Smoc mutation (0 available); any Ctnnb1 mutation (49 available)
Sox9em1(cre/ERT2)Tchn mutation (1 available); any Sox9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:322311 )
• increased number of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal adenocarcinomas and more aggressive progression of colorectal carcinogenesis

neoplasm
increased incidence of tumors by chemical induction ( J:322311 )
• increased number of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal adenocarcinomas and more aggressive progression of colorectal carcinogenesis




Genotype
MGI:7491702
cn3
Allelic
Composition		 Sox9em1(cre/ERT2)Tchn/Sox9+
Stk26tm2.1Zzh/Stk26tm2.1Zzh
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9em1(cre/ERT2)Tchn mutation (1 available); any Sox9 mutation (33 available)
Stk26tm2.1Zzh mutation (0 available); any Stk26 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:322311 )
• increased number of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal adenocarcinomas and more aggressive progression of colorectal carcinogenesis

neoplasm
increased incidence of tumors by chemical induction ( J:322311 )
• increased number of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colorectal adenocarcinomas and more aggressive progression of colorectal carcinogenesis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory