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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dnm2tm1Ueli
targeted mutation 1, Ueil Suter
MGI:6388413
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Dnm2tm1Ueli/Dnm2tm2.1Ics
Tg(Mpz-cre)26Mes/0
involves: C57BL/6J * C57BL/6N * FVB/NTac MGI:6506449


Genotype
MGI:6506449
cn1
Allelic
Composition
Dnm2tm1Ueli/Dnm2tm2.1Ics
Tg(Mpz-cre)26Mes/0
Genetic
Background
involves: C57BL/6J * C57BL/6N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm2tm1Ueli mutation (0 available); any Dnm2 mutation (100 available)
Dnm2tm2.1Ics mutation (0 available); any Dnm2 mutation (100 available)
Tg(Mpz-cre)26Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice show severe demyelinating neuropathy
• nerves show a strong reduction of myelinated axons at P24, with an increase in the number of sorted myelin-competent axons that are not enwrapped by myelin
• cells with engulfed myelin inclusions, indicative of ongoing demyelination, are commonly seen in nerves at P24
• however, the number of sorted axons and numbers of structural myelin aberrations are not changed
• no morphological changes are seen in tibial nerves or sciatic nerves at P5, indicating normal radial axonal sorting and correct onset of myelination
• electrophysiology shows decreased compound muscle action potential amplitude at P24
• electrophysiology shows reduced motor nerve conduction velocity at P24
• compound sensory nerve conduction velocity and compound sensory amplitude are not detectible in P24 mice





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory