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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ngftm1(NGF*)Cat
targeted mutation 1, Antonio Cattaneo
MGI:6388456
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ngftm1(NGF*)Cat/Ngftm1(NGF*)Cat involves: 129S1/Sv * 129X1/SvJ MGI:6388457
ht2
Ngftm1(NGF*)Cat/Ngf+ involves: 129S1/Sv * 129X1/SvJ MGI:6388458


Genotype
MGI:6388457
hm1
Allelic
Composition
Ngftm1(NGF*)Cat/Ngftm1(NGF*)Cat
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngftm1(NGF*)Cat mutation (0 available); any Ngf mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die by P30 (J:282017)
• mice die by the first month of life (J:284096)
• treatment of pregnant dams and pups with mouse NGF (from beginning of gestation until 10 days post-delivery followed by intranasal and subcutaneous NGF administration to pups) fully rescues the early lethality (J:284096)

growth/size/body
• body weight at P15, but not at birth, is lower
• administration of mouse NGF restores body weight for the first 2 weeks

nervous system
• density of ChAT+ neurons in the striatum is increased
• density of ChAT+ neurons in the striatum is increased
• however, density of ChAT+ neurons in the basal forebrain (medial septum and nucleus basalis of Meynert) are unchanged

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary sensory and autonomic neuropathy type 5 DOID:0070145 OMIM:608654
J:284096




Genotype
MGI:6388458
ht2
Allelic
Composition
Ngftm1(NGF*)Cat/Ngf+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ngftm1(NGF*)Cat mutation (0 available); any Ngf mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice show no learning or memory deficits in the Morris water maze, in the object recognition test, in exploratory activity and preference index
• a non-noxious stimulus (small piece of tape applied to the back) takes more time to induce a removal reaction than in controls at 6 months of age, but not at 2 months, indicating that mice are less sensitive to somatosensory inputs
• however, response to gentle stroking of the glabrous skin is normal
• chemical nociception induced by capsaicin injection in the hindpaw is impaired at 2 months and 6 months of age
• thermal nociception is normal at 2 month of age but decreases by 6 months of age, with adults showing a higher latency to respond to high-temperature stimulus
• cold sensitivity, measured by topical acetone application on the hindpaw, is reduced at 2 and 6 months of age

integument
• mice show a reduction in hairy and glabrous skin sensory innervation at 6 months of age, but not at 2 months
• however, mice show normal sympathetic innervation of key target organs such as the heart, stomach, kidney, spleen

nervous system
N
• mice show normal numbers of DRG neurons at P5, 2 months, and 6 months, normal numbers of SCG, normal density of ChAT+ neurons in the medial septum and striatum, normal conduction velocities of the 3 main sensory fiber populations, ABeta, Adelta, and C fibers, and normal Schaffer collateral-CA1 long-term potentiation
• mice show a reduction in hairy and glabrous skin sensory innervation at 6 months of age, but not at 2 months
• however, mice show normal sympathetic innervation of key target organs such as the heart, stomach, kidney, spleen
• cross-sectional area of the sciatic nerve is decreased
• sciatic nerve shows a decrease in the number of nonmyelinated axons
• however, the number of myelinated axons in the sciatic nerve is unaffected

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary sensory and autonomic neuropathy type 5 DOID:0070145 OMIM:608654
J:282017





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory