mortality/aging
• mice die by P30
(J:282017)
• mice die by the first month of life
(J:284096)
• treatment of pregnant dams and pups with mouse NGF (from beginning of gestation until 10 days post-delivery followed by intranasal and subcutaneous NGF administration to pups) fully rescues the early lethality
(J:284096)
|
growth/size/body
• body weight at P15, but not at birth, is lower
• administration of mouse NGF restores body weight for the first 2 weeks
|
nervous system
• density of ChAT+ neurons in the striatum is increased
|
• density of ChAT+ neurons in the striatum is increased
• however, density of ChAT+ neurons in the basal forebrain (medial septum and nucleus basalis of Meynert) are unchanged
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hereditary sensory and autonomic neuropathy type 5 | DOID:0070145 |
OMIM:608654 |
J:284096 |