Phenotypes associated with this allele

• Allele Symbol: Metrn^tm1.1Kong
• Allele Name: targeted mutation 1.1, Young-Yun Kong
• Allele ID: MGI:6388733
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Metrn^tm1.1Kong/Metrn^tm1.1Kong	B6.129P2(Cg)-Metrn^tm1.1Kong	MGI:6388735

Genotype
MGI:6388735

hm1

• Allelic Composition: Metrn^tm1.1Kong/Metrn^tm1.1Kong
• Genetic Background: B6.129P2(Cg)-Metrn^tm1.1Kong

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:283312 )

• embryos die between E7 and E8.5

growth/size/body

decreased embryo size ( J:283312 )

• viable E7.5 embryos are smaller, especially in the embryonic region

embryo

abnormal gastrulation ( J:283312 )

• gastrulation is impaired

abnormal endoderm development ( J:283312 )

• expression of endoderm-specific markers is severely affected indicating that specification of the definitive endoderm is blocked

• however, embryos develop normally prior to implantation

abnormal mesendoderm development ( J:283312 )

• embryos between E7 and E7.25 show abnormal accumulation of cells in the presumptive primitive streak toward the posterior or distal region of the embryo, suggesting impaired mesendoderm development

decreased embryo size ( J:283312 )

• viable E7.5 embryos are smaller, especially in the embryonic region