Phenotypes associated with this allele

• Allele Symbol: Niban3^tm1Jyw
• Allele Name: targeted mutation 1, Ji-Yang Wang
• Allele ID: MGI:6388736
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Niban3^tm1Jyw/Niban3^tm1Jyw	B6.Cg-Niban3^tm1Jyw	MGI:6388739

Genotype
MGI:6388739

hm1

• Allelic Composition: Niban3^tm1Jyw/Niban3^tm1Jyw
• Genetic Background: B6.Cg-Niban3^tm1Jyw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell proliferation ( J:282961 )

• spleen B cells show a moderate increase in survival and proliferation in response to F(ab)2 alpha-IgM antibodies

• spleen B cells show increased survival and undergo more cell divisions in response to BCR stimulation

• spleen B cells show a moderately increased response to LPS stimulation

abnormal B cell differentiation ( J:282961 )

• mice exhibit a partial block of B-cell maturation in the spleen

abnormal class switch recombination ( J:282961 )

• class-switch recombination induced by CD40L+alpha-CD8+IL-4 is reduced in B cells

• however, class-switch recombination induced by LPS+IL-4 occurs normally

abnormal transitional stage B cell morphology ( J:282961 )

• increase of IgM^lowIgD^high transitional B cells in the spleen

• decrease of IgM^lowIgD^high mature B cell population in the spleen

• however, the proportion of B220⁺CD21^highCD23^low marginal zone B cells appears normal

increased transitional stage T2 B cell number ( J:282961 )

• increase of the T2 population of transitional B cells in the spleen

decreased B-1a cell number ( J:282961 )

• reduction of B-1a cells in the peritoneal cavity

increased B cell number ( J:282961 )

• aged mice show a higher frequency of clonal expansion of B cells in the spleen and lymph nodes

increased follicular B cell number ( J:282961 )

• aged mice show an increase in the proportion of B220+, but not CD3+, in the spleen; majority of these cells are follicular B cells

abnormal B cell calcium ion homeostasis ( J:282961 )

• B cells show elevated calcium influx in response to BCR cross-linking

decreased IgA level ( J:282961 )

• slight decrease of serum IgA

decreased IgG2c level ( J:282961 )

• slight decrease of serum IgG2c

increased IgG level ( J:282961 )

• aged mice show a greater decrease in the total serum IgG levels

increased IgG1 level ( J:282961 )

• production of both total and high-affinity NP-specific IgG1 antibodies is enhanced

increased IgG3 level ( J:282961 )

• moderate increase in the steady state levels of IgG3

• production of NP-specific IgG3 is elevated

• aged mice show a greater increase in serum IgG3

increased IgM level ( J:282961 )

• moderate increase in the steady state levels of serum IgM

• production of NP-specific IgM is elevated

• aged mice show a greater increase in serum IgM

enhanced humoral immune response ( J:282961 )

• humoral immune responses to a T-independent antigen NP-Ficoll are enhanced

• responses to a T-dependent antigen NP coupled to CGG are enhanced

• increase in antibody-forming cells that secrete low- and high-affinity NP-specific antibodies

homeostasis/metabolism

abnormal B cell calcium ion homeostasis ( J:282961 )

• B cells show elevated calcium influx in response to BCR cross-linking

hematopoietic system

increased B cell proliferation ( J:282961 )

• spleen B cells show a moderate increase in survival and proliferation in response to F(ab)2 alpha-IgM antibodies

• spleen B cells show increased survival and undergo more cell divisions in response to BCR stimulation

• spleen B cells show a moderately increased response to LPS stimulation

abnormal B cell differentiation ( J:282961 )

• mice exhibit a partial block of B-cell maturation in the spleen

abnormal class switch recombination ( J:282961 )

• class-switch recombination induced by CD40L+alpha-CD8+IL-4 is reduced in B cells

• however, class-switch recombination induced by LPS+IL-4 occurs normally

abnormal transitional stage B cell morphology ( J:282961 )

• increase of IgM^lowIgD^high transitional B cells in the spleen

• decrease of IgM^lowIgD^high mature B cell population in the spleen

• however, the proportion of B220⁺CD21^highCD23^low marginal zone B cells appears normal

increased transitional stage T2 B cell number ( J:282961 )

• increase of the T2 population of transitional B cells in the spleen

decreased B-1a cell number ( J:282961 )

• reduction of B-1a cells in the peritoneal cavity

increased B cell number ( J:282961 )

• aged mice show a higher frequency of clonal expansion of B cells in the spleen and lymph nodes

increased follicular B cell number ( J:282961 )

• aged mice show an increase in the proportion of B220+, but not CD3+, in the spleen; majority of these cells are follicular B cells

abnormal B cell calcium ion homeostasis ( J:282961 )

• B cells show elevated calcium influx in response to BCR cross-linking

decreased IgA level ( J:282961 )

• slight decrease of serum IgA

decreased IgG2c level ( J:282961 )

• slight decrease of serum IgG2c

increased IgG level ( J:282961 )

• aged mice show a greater decrease in the total serum IgG levels

increased IgG1 level ( J:282961 )

• production of both total and high-affinity NP-specific IgG1 antibodies is enhanced

increased IgG3 level ( J:282961 )

• moderate increase in the steady state levels of IgG3

• production of NP-specific IgG3 is elevated

• aged mice show a greater increase in serum IgG3

increased IgM level ( J:282961 )

• moderate increase in the steady state levels of serum IgM

• production of NP-specific IgM is elevated

• aged mice show a greater increase in serum IgM

cellular

increased B cell proliferation ( J:282961 )

• spleen B cells show a moderate increase in survival and proliferation in response to F(ab)2 alpha-IgM antibodies

• spleen B cells show increased survival and undergo more cell divisions in response to BCR stimulation

• spleen B cells show a moderately increased response to LPS stimulation