Phenotypes associated with this allele

• Allele Symbol: Tonsl^em1Tjch
• Allele Name: endonuclease-mediated mutation 1, Tae-Joon Cho
• Allele ID: MGI:6389087
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tonsl^em1Tjch/Tonsl^em1Tjch	involves: C57BL/6	MGI:6389088
ht2	Tonsl^em1Tjch/Tonsl^+	involves: C57BL/6	MGI:6389089

Genotype
MGI:6389088

hm1

• Allelic Composition: Tonsl^em1Tjch/Tonsl^em1Tjch
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:282817 )

• embryonic lethality most likely between E11.5-E12.5

growth/size/body

embryonic growth retardation ( J:282817 )

• embryos are growth retarded at E10.5, E11.5, and E12.5, with E12.5 embryos still in the process of turning

embryo

absent vitelline blood vessels ( J:282817 )

• yolk sacs lack visible blood vessels

embryonic growth retardation ( J:282817 )

• embryos are growth retarded at E10.5, E11.5, and E12.5, with E12.5 embryos still in the process of turning

small visceral yolk sac ( J:282817 )

cardiovascular system

absent vitelline blood vessels ( J:282817 )

• yolk sacs lack visible blood vessels

internal hemorrhage ( J:282817 )

• E12.5 embryos show internal hemorrhage

Genotype
MGI:6389089

ht2

• Allelic Composition: Tonsl^em1Tjch/Tonsl⁺
• Genetic Background: involves: C57BL/6

normal phenotype

no abnormal phenotype detected ( J:282817 )

• heterozygotes are fertile and show normal gross morphology