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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Abcc9em2Nich
endonuclease-mediated mutation 2, Colin G Nichols
MGI:6389242
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Abcc9em2Nich/Abcc9em2Nich involves: C57BL/6J * CBA/J MGI:6389243


Genotype
MGI:6389243
hm1
Allelic
Composition
Abcc9em2Nich/Abcc9em2Nich
Genetic
Background
involves: C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abcc9em2Nich mutation (0 available); any Abcc9 mutation (101 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mild left ventricular dilatation in diastole
• left ventricle fractional shortening is decreased
• echocardiography shows decreased left ventricle fractional shortening and a small, but significant, increase in left ventricular internal dimension in diastole
• blood pressure is increased

muscle
• left ventricle fractional shortening is decreased
• while mice perform normally in the initial trail of the inverted screen test of strength, in subsequent trials, mice show decreased performance, with mice remaining inverted a shorter time than wild-type mice indicating increased fatigability

nervous system
• inside-out patch clamp recordings from ventricular myocytes and aortic smooth muscle cells show that functional K(ATP) channels are absent

behavior/neurological
N
• mice do not exhibit cognitive or behavioral defects, including no deficits in learning and memory and do not show anxiety-like behaviors





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory