Phenotypes associated with this allele

• Allele Symbol: Tg(Camk2a-MAPT)#Atak
• Allele Name: transgene insertion, Akihiko Takashima
• Allele ID: MGI:6389815
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Camk2a-MAPT)#Atak/0	involves: C57BL/6J	MGI:6390148

Genotype
MGI:6390148

tg1

• Allelic Composition: Tg(Camk2a-MAPT)#Atak/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired spatial learning ( J:130237 )

• aged (20-24 months old) mice show impaired place learning in the Morris water maze

• however, adult (9-13 months old) mice do not differ from controls in place learning

abnormal spatial reference memory ( J:130237 , J:167329 )

• aged (20-24 months old) mice show impaired memory in the Morris water maze (J:130237)

• however, adult (9-13 months old) mice do not differ from controls in memory (J:130237)

nervous system

abnormal brain morphology ( J:167329 )

• brains of aged mice exhibit hyperphosphorylated tau

• however, aged mice do not exhibit neuronal loss and do not produce sarcosyl-insoluble tau aggregates in the brain

abnormal parahippocampal gyrus morphology ( J:130237 )

• aged mice exhibit accumulation of hyperphosphorylated tau in the parahippocampal cortex

• however, aged mice do not form sarcosyl-insoluble tau aggregates, neurofibrillary tangles, or neuronal loss

decreased dendritic spine density ( J:130237 )

• number of dendritic spines of entorhinal cortical layer II neurons is reduced in aged mice

abnormal synapse morphology ( J:130237 , J:167329 )

• aged mice exhibit synapse loss in layer II neurons of the entorhinal cortex (J:130237)

• aged mice exhibit fewer synapses in the entorhinal cortex indicating synaptic loss (J:167329)

abnormal neuron physiology ( J:130237 )

• aged mice exhibit reduced neuronal activity the parahippocampal region including the perirhinal cortex, postrhinal cortex, and lateral and medial entorhinal cortices