Phenotypes associated with this allele

• Allele Symbol: Tg(Camk2a-MAPT*P301L)#Atak
• Allele Name: transgene insertion, Akihiko Takashima
• Allele ID: MGI:6389818
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Camk2a-MAPT*P301L)#Atak/0	involves: C57BL/6	MGI:6390152

Genotype
MGI:6390152

tg1

• Allelic Composition: Tg(Camk2a-MAPT*P301L)#Atak/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain morphology ( J:167329 )

• brains of aged mice exhibit lower levels of fully phosphorylated tau and show sarcosyl-insoluble tau aggregates

• however, mice do not show formation of neurofibrillary tangles in neurons and do not exhibit synaptic loss in the entorhinal cortex

neuron degeneration ( J:167329 )

• density of neurons in temporal area, entorhinal cortex, lateral amygdala, and basolateral amygdala is reduced in aging mice indicating neuronal loss

• neuron loss is seen in various brain regions that also exhibit sarcosyl-insoluble tau aggregates

behavior/neurological

behavior/neurological phenotype ( J:167329 )

N • mice exhibit normal behavior in the Morris water maze, indicating no memory impairment and the ability to form place memories