integument
blistering
(
J:280214
)
• neonates exhibit blistered paws shortly after birth, followed by formation of more severe blisters and open wounds characteristic of skin fragility
• blistered mice transplanted with human-dermis-derived cells expressing the ATP-binding cassette sub-family B member 5 glycoprotein (ABCB5) show a dramatic improvement in survival
|
immune system
• peripheral blood shows lack of B cells
|
• peripheral blood shows lack of NK lymphoid cells
|
• peripheral blood shows lack of T cells
|
hematopoietic system
• peripheral blood shows lack of B cells
|
• peripheral blood shows lack of NK lymphoid cells
|
• peripheral blood shows lack of T cells
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
recessive dystrophic epidermolysis bullosa | DOID:0060642 |
OMIM:226600 |
J:280214 |