Phenotypes associated with this allele

• Allele Symbol: Ttc29^em1Fzh
• Allele Name: endonuclease-mediated mutation 1, Feng Zhang
• Allele ID: MGI:6391112
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ttc29^em1Fzh/Ttc29^em1Fzh	involves: C57BL/6	MGI:6391118

Genotype
MGI:6391118

hm1

• Allelic Composition: Ttc29^em1Fzh/Ttc29^em1Fzh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:283265 )

♂N • normal flagellar beating

♂N • no significant difference in testis weight

abnormal sperm end piece morphology ( J:283265 )

♂ • in cauda epididymis spermatozoa

abnormal sperm midpiece morphology ( J:283265 )

♂ • in cauda epididymis spermatozoa

♂ • absence of central microtubule pair (CP)

♂ • disorganized outer dense fiber (ODF)

abnormal sperm principal piece morphology ( J:283265 )

♂ • disorganized outer dense fiber (ODF)

♂ • absence of central microtubule pair (CP)

♂ • in cauda epididymis spermatozoa

hairpin sperm flagellum ( J:283265 )

♂

decreased sperm progressive motility ( J:283265 )

♂ • significantly reduced curvilinear velocity (VCL), straight-line velocity (VSL), and average-path velocity (VAP)

asthenozoospermia ( J:283265 )

♂ • higher rate of immotility

♂ • significantly reduced curvilinear velocity (VCL), straight-line velocity (VSL), and average-path velocity (VAP)

reduced male fertility ( J:283265 )

♂ • significantly fewer litters and reduced litter size during 3 months mating with WT females

♂ • significantly fewer two-cell embryos and blastocysts when using sperm in IVF experiments

cellular

abnormal sperm end piece morphology ( J:283265 )

♂ • in cauda epididymis spermatozoa

abnormal sperm midpiece morphology ( J:283265 )

♂ • in cauda epididymis spermatozoa

♂ • absence of central microtubule pair (CP)

♂ • disorganized outer dense fiber (ODF)

abnormal sperm principal piece morphology ( J:283265 )

♂ • disorganized outer dense fiber (ODF)

♂ • absence of central microtubule pair (CP)

♂ • in cauda epididymis spermatozoa

hairpin sperm flagellum ( J:283265 )

♂

decreased sperm progressive motility ( J:283265 )

♂ • significantly reduced curvilinear velocity (VCL), straight-line velocity (VSL), and average-path velocity (VAP)

asthenozoospermia ( J:283265 )

♂ • higher rate of immotility

♂ • significantly reduced curvilinear velocity (VCL), straight-line velocity (VSL), and average-path velocity (VAP)