Phenotypes associated with this allele

• Allele Symbol: Gpr63^em2Rstot
• Allele Name: endonuclease-mediated mutation 2, Rolf W Stottmann
• Allele ID: MGI:6391253
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gpr63^em2Rstot/Gpr63^em2Rstot Ttc21b^aln/Ttc21b^aln	involves: A/J * C57BL/6 * FVB	MGI:6392828
cx2	Gpr63^em1Rstot/Gpr63^em2Rstot Ttc21b^aln/Ttc21b^aln	involves: A/J * C57BL/6 * FVB	MGI:6392831

Genotype
MGI:6392828

cx1

• Allelic Composition: Gpr63^em2Rstot/Gpr63^em2Rstot; Ttc21b^aln/Ttc21b^aln
• Genetic Background: involves: A/J * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

spina bifida cystica ( J:282171 )

• in 5 of 9 E10.5-14.5 embryos

spina bifida occulta ( J:282171 )

limbs/digits/tail

polydactyly ( J:282171 )

• in 1 of 9 E10.5-14.5 embryos and in 2 surviving (of 8) E17.5-18.5 embryos

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:282171 )

• in 6 of 8 E17.5-18.5 embryos

nervous system

spina bifida cystica ( J:282171 )

• in 5 of 9 E10.5-14.5 embryos

spina bifida occulta ( J:282171 )

exencephaly ( J:282171 )

• in 2 surviving (of 8) E17.5-18.5 embryos and 8 of 9 E10.5-14.5 embryos

skeleton

spina bifida occulta ( J:282171 )

growth/size/body

spina bifida cystica ( J:282171 )

• in 5 of 9 E10.5-14.5 embryos

Genotype
MGI:6392831

cx2

• Allelic Composition: Gpr63^em1Rstot/Gpr63^em2Rstot; Ttc21b^aln/Ttc21b^aln
• Genetic Background: involves: A/J * C57BL/6 * FVB

growth/size/body

microcephaly ( J:282171 )

• 25% reduction in forebrain area compared to Ttc21b^aln/ Ttc21b^aln;Gpr63^em1Rstot/Gpr63^rs13477613-T mice

nervous system

forebrain hypoplasia ( J:282171 )

• 25% reduction in forebrain area compared to Ttc21b^aln/ Ttc21b^aln;Gpr63^em1Rstot/Gpr63^rs13477613-T mice