Phenotypes associated with this allele

• Allele Symbol: Cd2bp2^tm1.1Tbh
• Allele Name: targeted mutation 1.1, Tobias Huber
• Allele ID: MGI:6392026
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd2bp2^tm1.1Tbh/Cd2bp2^tm1.1Tbh Tg(T-cre)1Lwd/0	B6OlaHsd.Cg-Cd2bp2^tm1.1Tbh Tg(T-cre)1Lwd	MGI:6392048
cn2	Cd2bp2^tm1.1Tbh/Cd2bp2^tm1.1Tbh Tg(Mx1-cre)1Cgn/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * CBA/J	MGI:6392051
cn3	Cd2bp2^tm1.1Tbh/Cd2bp2^tm1.1Tbh Tg(NPHS2-cre)295Lbh/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * SJL	MGI:6392043
cn4	Cd2bp2^tm1.1Tbh/Cd2bp2^tm1.1Tbh Tg(Tek-cre)1Ywa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * SJL	MGI:6392049

Genotype
MGI:6392048

cn1

• Allelic Composition: Cd2bp2^tm1.1Tbh/Cd2bp2^tm1.1Tbh; Tg(T-cre)1Lwd/0
• Genetic Background: B6OlaHsd.Cg-Cd2bp2^tm1.1Tbh Tg(T-cre)1Lwd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:283435 )

• mice die around E10.5

embryo

abnormal vitelline vein morphology ( J:283435 )

• delayed vasculatization

embryonic growth arrest ( J:283435 )

cardiovascular system

abnormal vitelline vein morphology ( J:283435 )

• delayed vasculatization

hemorrhage ( J:283435 )

Genotype
MGI:6392051

cn2

• Allelic Composition: Cd2bp2^tm1.1Tbh/Cd2bp2^tm1.1Tbh; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * CBA/J

immune system

impaired macrophage phagocytosis ( J:283435 )

cellular

impaired macrophage phagocytosis ( J:283435 )

hematopoietic system

impaired macrophage phagocytosis ( J:283435 )

Genotype
MGI:6392043

cn3

• Allelic Composition: Cd2bp2^tm1.1Tbh/Cd2bp2^tm1.1Tbh; Tg(NPHS2-cre)295Lbh/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * SJL

mortality/aging

premature death ( J:283435 )

• premature death at 15 to 30 weeks of age

renal/urinary system

increased mesangial cell number ( J:283435 )

increased urine protein level ( J:283435 )

• severe starting at 2 months of age

podocyte foot process effacement ( J:283435 )

• however, blood capillaries and fenestration of the endothelium are unchanged

glomerulosclerosis ( J:283435 )

renal cast ( J:283435 )

• in the renal tubules

growth/size/body

weight loss ( J:283435 )

• starting at 10 weeks of age

homeostasis/metabolism

increased urine protein level ( J:283435 )

• severe starting at 2 months of age

cellular

increased mesangial cell number ( J:283435 )

Genotype
MGI:6392049

cn4

• Allelic Composition: Cd2bp2^tm1.1Tbh/Cd2bp2^tm1.1Tbh; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6N * SJL

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:283435 )

• mice die around E11.5